Carotid Doppler Parameters and Post-Induction Hypotension

NCT07385274 | Completed

• 1 other identifier: 1-25-1378
• Study Type: observational
• Target: 91
• Locations: 1 country
• Sites: 1

Brief Summary

Post-induction hypotension is a common complication following the induction of general anesthesia and is associated with adverse postoperative outcomes. Patients undergoing gynecologic oncology surgery represent a particularly vulnerable population due to advanced age, high comorbidity burden, and increased frailty, which may predispose them to perioperative hemodynamic instability. This prospective observational study aims to evaluate whether carotid Doppler ultrasonography parameters, including corrected flow time and other flow-related indices, can predict the occurrence of post-induction hypotension specifically in patients undergoing gynecologic oncology surgery. Adult patients scheduled for elective gynecologic oncology surgery under general anesthesia will undergo pre-induction carotid Doppler ultrasonography as part of routine perioperative assessment. Baseline clinical characteristics, including the Charlson Comorbidity Index and Clinical Frailty Scale, will be recorded for each participant. Hemodynamic parameters will be recorded following anesthetic induction, and the development of post-induction hypotension will be assessed. The findings of this study may help identify high-risk patients within the gynecologic oncology population and support the use of non-invasive carotid Doppler measurements, comorbidity burden, and frailty assessment for perioperative risk stratification in this specific surgical group.

Conditions

Gynecologic Oncology Patient; Ultrasonography, Doppler; Post-induction Hypotension (PIH)

Keywords

Corrected Flow Time; Peak Systolic Velocity; Ultrasonography, Doppler; carotid arteries

Outcome Measures

Primary Outcomes (1)

• Occurrence of Post-Induction Hypotension

  Post-induction hypotension defined as a mean arterial pressure \<65 mmHg within the early post-induction period following induction of general anesthesia.

  Within the first 20 minutes after induction of general anesthesia

Secondary Outcomes (5)

• Corrected Flow Time Measured by Carotid Doppler Ultrasonography

  Pre-induction assessment

• Delta Peak Systolic Velocity Measured by Carotid Doppler Ultrasonography

  Pre-induction assessment

• Carotid Flow Volume Measured by Doppler Ultrasonography

  Pre-induction assessment

• Acceleration Index Measured by Carotid Doppler Ultrasonography

  Pre-induction assessment

• Acceleration Time Measured by Carotid Doppler Ultrasonography

  Pre-induction assessment

Study Arms (1)

Gynecologic Oncology Surgery Cohort

Prospective observational single-center cohort of adult patients undergoing elective gynecologic oncology surgery under general anesthesia. Pre-induction carotid Doppler ultrasonography parameters were recorded to evaluate the prediction of post-induction hypotension. Baseline comorbidity burden and frailty status were assessed using the Charlson Comorbidity Index and Clinical Frailty Scale. No study-specific interventions were performed.

Other: pre- induction carotid doppler ultrasonography

Interventions

pre- induction carotid doppler ultrasonography OTHER

patients undergo non-invasive carotid doppler ultrasonography

Gynecologic Oncology Surgery Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult female patients aged 18 years or older undergoing elective gynecologic oncology surgery under general anesthesia. All participants are evaluated prospectively in a single-center setting. Pre-induction carotid Doppler ultrasonography is performed as part of the perioperative assessment. Baseline comorbidity burden and frailty status are assessed using the Charlson Comorbidity Index and Clinical Frailty Scale. Patients meeting predefined inclusion and exclusion criteria are enrolled consecutively.

You may qualify if:

• Female patients aged 18 years or older
• Scheduled for elective gynecologic oncology surgery under general anesthesia
• Planned standard anesthetic induction
• Ability to provide written informed consent

You may not qualify if:

• Refusal to participate in the study
• Inability to obtain informed consent, including patients with dementia
• Emergency surgery
• American Society of Anesthesiologists (ASA) physical status IV or higher
• Cardiac rhythm other than sinus rhythm
• Autonomic nervous system disorders
• Atrial fibrillation with rapid ventricular response
• Pregnancy
• Sepsis or septic shock
• Significant valvular heart disease or peripheral vascular disease
• Anticipated difficult ventilation and/or difficult intubation
• Left ventricular ejection fraction \<40%
• Severe aortic valve stenosis
• Morbid obesity (body mass index \>40 kg/m²)
• Presence of implanted cardiac pacemaker or implantable cardioverter-defibrillator

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye)

Location

Study Officials

• EMINE MUGE GOKSOY, MD

  Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 4, 2026
• Study Start: March 1, 2025
• Primary Completion: September 25, 2025
• Study Completion: September 30, 2025
• Last Updated: February 4, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)