Targeted Assessment of Cognition and Tactical-performance With Ingested Ketones

NCT07771790 | Recruiting

• 2 other identifiers: STUDY00007647: TACTIKFP00009695
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to determine whether consuming a commercially available exogenous ketone supplement (KetoneIQ®) affects cognition, specifically marksmanship, under physical stress (i.e., exhaustive exercise). The main questions we seek to answer are:

• Does the supplement save cognitive performance under stress compared to a placebo?
• Does the supplement improve marksmanship under stress compared to a placebo?

Conditions

Cognition

Keywords

Exogenous Ketones; Cognition; Tactical Athlete

Outcome Measures

Primary Outcomes (1)

• Cognitive Performance

  Changes in Score for the Trail Making Test, Psychomotor Vigilance Test, and Flanker Test.

  Baseline (minute 0) to Post Suppelementation (minute 45) to Post Exercise (minute 60)

Secondary Outcomes (5)

• Changes in Circulating Concentration of Brain Derieved Neurotrophic Factor

  Baseline (minute 0) to post supplementation (minute 45) to post exercise (minute 60)

• Changes in Circulating Catecholamines Concetrations

  From baseline (minute 0) to post supplemenation (minute 45) to post exercise (minute 60)

• Changes in Circulating Cortisol Concentration

  From baseline (minute 0) to post supplemetation (minute 45) to post exercise (minute 60)

• Weapons Familarization Score

  Post Exercise (minute 60)

• Marksmanship efficiency

  Post Exercise (minute 60)

Study Arms (2)

KetoneIQ®

EXPERIMENTAL

Supplement of study. KetoneIQ® dosed at 0.6g/kg body weight

Dietary Supplement: KetoneIQ®

Placebo

PLACEBO COMPARATOR

Flavor, texture, color matched. Very low calorie.

Dietary Supplement: Placebo

Interventions

KetoneIQ® DIETARY_SUPPLEMENT

Acute dosage at 0.6g/kg of bodyweight, split into 2 boluses of 0.4 and 0.2g/kg seperated by 45 mins

KetoneIQ®

Placebo DIETARY_SUPPLEMENT

Taste, texture, and color matched very low calorie placebo

Placebo

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Active Member of an accredited Law Enforcement Special Weapons and Tactics Team (SWAT)
• Health and capable of meeting testing requirements

You may not qualify if:

• Following a low-carbohydrate ketogenic diet
• Self-reported Pregnancy
• Allergy to testing materials
• Currently using exogenous ketone supplements within one week of testing

Sponsors & Collaborators

• Florida State University: lead

Study Sites (1)

Institute of Sports Sciences and Medicine

Tallahassee, Florida, 32306, United States

RECRUITING

Study Officials

• Michael J Ormsbee, PhD

  Florida State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Michael J Ormsbee, PhD

CONTACT

850-644-2194; mormsbee@fsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 10, 2026
• First Posted: August 18, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): May 31, 2027
• Study Completion (Estimated): May 31, 2027
• Last Updated: September 2, 2026

Record last verified: 2026-08

Locations

US (1)