High-Amplitude Functional Exercises in Older Adults With Mild Cognitive Impairment

NCT07762235 | Not Yet Recruiting

• 1 other identifier: 104
• Study Type: interventional
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will investigate the effects of dual-task-based high-amplitude functional exercises on balance and functional mobility in older adults with mild cognitive impairment. A total of 36 participants aged 65 years and older will be randomly assigned to either a high-amplitude functional exercise group or a traditional balance and mobility exercise group. Both groups will participate in exercise sessions four times per week for four weeks, with each session lasting 60 minutes. The effects of the exercise programs will be evaluated by assessing balance, functional mobility, dual-task performance, walking performance, fear of falling, and independence in daily activities before and after the intervention.

Conditions

Mild Cognitive Impairment (MCI); Exercises

Keywords

Mild Cognitive Impairment; Older Adults; High-Amplitude Functional Exercises; Dual-Task Training; Functional Mobility; Dual-Task Cost

Outcome Measures

Primary Outcomes (3)

• Dual-Task Timed Up and Go Test

  The Dual-Task TUG will assess functional mobility under cognitive load by adding a cognitive task to the standard Timed Up and Go test. Test performance will be recorded as the time required to complete the task.

  Baseline to post-intervention (4 weeks)

• Mini-BESTest

  The Mini-BESTest will be used to assess balance performance across anticipatory postural control, reactive postural control, sensory orientation, and dynamic gait. The scale consists of 14 items scored from 0 to 2, with a maximum total score of 28. Higher scores indicate better balance performance.

  Baseline to post-intervention (4 weeks)

• Five Times Sit-to-Stand Test

  The Five Times Sit-to-Stand Test will be used to assess lower-extremity muscle strength and functional capacity. The time required to complete five full sit-to-stand repetitions will be recorded.

  Baseline to post-intervention (4 weeks)

Secondary Outcomes (7)

• Timed Up and Go Test (TUG)

  Baseline to post-intervention (4 weeks)

• Edinburgh Visual Gait Score

  Baseline to post-intervention (4 weeks)

• Dual-Task Walking Speed

  Baseline to post-intervention (4 weeks)

• Dual-Task Cost

  Baseline to post-intervention (4 weeks)

• Falls Efficacy Scale-International I

  Baseline to post-intervention (4 weeks)

Study Arms (2)

Dual-Task-Based High-Amplitude Functional Exercise

EXPERIMENTAL

Other: Dual-Task-Based High-Amplitude Functional Exercise Program

Traditional Balance and Mobility Exercise

ACTIVE COMPARATOR

Other: Traditional Balance and Mobility Exercise Group

Interventions

Dual-Task-Based High-Amplitude Functional Exercise Program OTHER

Participants will receive a dual-task-based high-amplitude functional exercise program consisting of high-amplitude functional movements combined with progressively challenging cognitive tasks. The program will be administered 4 times per week for 4 weeks, for a total of 16 sessions, with each session lasting 60 minutes. Exercise intensity will be prescribed as maximal effort, corresponding to 7-8/10 on the Borg Rating of Perceived Exertion Scale. The program will include seated and standing functional exercises, large-amplitude stepping movements, dynamic movements, large-amplitude walking, functional task activities, and complex functional tasks.

Dual-Task-Based High-Amplitude Functional Exercise

Traditional Balance and Mobility Exercise Group OTHER

Participants will receive a traditional balance and mobility exercise program administered 4 times per week for 4 weeks, for a total of 16 sessions, with each session lasting 60 minutes. Exercise intensity will be moderate, corresponding to 4-5/10 on the Borg Rating of Perceived Exertion Scale. The program will consist of motor tasks without cognitive dual-task components.

Traditional Balance and Mobility Exercise

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Living independently/actively in a nursing home.
• Diagnosis of Mild Cognitive Impairment (MCI) based on a standardized screening test, with a Montreal Cognitive Assessment (MoCA) score of 18-25.
• Ability to walk independently for at least 10 meters without an assistive device or with only a cane/single-point support.
• Sufficient vision and hearing capacity to follow dual-task instructions and exercise directions, which may be corrected with glasses or hearing aids.
• Stable medical condition that does not prevent participation in the exercise program throughout the study.

You may not qualify if:

• Diagnosis of dementia or severe cognitive impairment based on cognitive screening (MoCA \<17).
• Neurological conditions that primarily affect balance, such as Parkinson's disease, residual effects of stroke, multiple sclerosis, or cerebellar ataxia.
• Severe osteoarthritis, active inflammatory joint disease, or a history of major orthopedic surgery within the previous 6 months that could limit exercise performance.
• Uncontrolled hypertension, heart failure (NYHA Class III-IV), or cardiopulmonary instability causing symptoms during exercise.
• Advanced vestibular pathology or severe loss of proprioception in the lower extremities that could be the primary cause of balance impairment.

Sponsors & Collaborators

• Istinye University: lead

MeSH Terms

Conditions

Cognitive Dysfunction; Motor Activity

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Assistant Professor

Study Record Dates

• First Submitted: August 9, 2026
• First Posted: August 13, 2026
• Study Start (Estimated): August 20, 2026
• Primary Completion (Estimated): April 5, 2027
• Study Completion (Estimated): April 5, 2027
• Last Updated: August 13, 2026

Record last verified: 2026-08