Turkish Chronic Total Occlusion Percutaneous Coronary Intervention Registry

NCT07761624 | Not Yet Recruiting

• 2 other identifiers: TURK-CTO-2026-0133222
• Study Type: observational
• Target: 70,000
• Locations: 1 country
• Sites: 6

Brief Summary

The TURK CTO Registry is a prospective, multicenter, observational registry designed to evaluate the contemporary management and outcomes of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in Türkiye. The registry will include consecutive adult patients undergoing CTO PCI at participating centers. Detailed data on patient characteristics, cardiovascular risk factors, lesion and procedural characteristics, CTO crossing strategies, guidewires and devices, procedural techniques, radiation exposure, contrast use, procedural success, and in-hospital complications will be collected using a standardized electronic data collection system. The primary objective of the registry is to characterize contemporary CTO PCI practice in Türkiye and to evaluate procedural success and safety. Secondary objectives include identifying clinical, angiographic, and procedural factors associated with technical and procedural success, complications, resource utilization, and patient outcomes. The registry is expected to provide real-world, multicenter data on CTO PCI practice and to help identify factors associated with successful and safe CTO revascularization in Türkiye. No treatment or procedural strategy will be assigned by the study protocol; all clinical and procedural decisions will be made by the treating physicians according to routine clinical practice.

Conditions

Chronic Total Occlusion (CTO); Coronary Artery Disease

Keywords

chronic total occlusion; coronary artery disease; percutaneous coronary intervention; antegrade approach; retrograde approach; Turk-Cto Registry

Outcome Measures

Primary Outcomes (2)

• Technical Success of CTO PCI

  Technical success will be defined as successful CTO revascularization resulting in \<30% residual stenosis and restoration of TIMI grade 3 antegrade flow in the treated vessel at the completion of the CTO PCI procedure. The proportion of CTO PCI procedures achieving technical success will be assessed.

  At the end of the index CTO PCI procedure

• Procedural Success of CTO PCI

  Procedural success will be defined as achievement of technical success without the occurrence of an in-hospital major adverse event. The proportion of CTO PCI procedures meeting the predefined criteria for procedural success will be assessed.

  From the CTO PCI procedure through hospital discharge, typically within 7 days

Secondary Outcomes (13)

• In-Hospital Major Adverse Cardiovascular and Cerebrovascular Events

  From the CTO PCI procedure through hospital discharge, typically within 7 days.

• CTO PCI-Related Procedural Complications

  During the CTO PCI procedure through hospital discharge, typically within 7 days.

• Major Adverse Cardiovascular and Cerebrovascular Events During Follow-up

  30 days, 6 months, 12 months, 24 months, and 36 months after the CTO PCI procedure.

• CTO Target-Vessel Reocclusion

  Up to 36 months after the CTO PCI procedure.

• Change in Left Ventricular Ejection Fraction

  Baseline and up to 36 months after the CTO PCI procedure.

Study Arms (1)

CTO PCI Cohort

Adult patients (≥18 years) undergoing attempted percutaneous coronary intervention (PCI) for at least one coronary chronic total occlusion (CTO) at participating centers in Türkiye will be prospectively enrolled. The cohort will include both successful and unsuccessful CTO PCI procedures, as well as repeat CTO PCI attempts. If a patient undergoes more than one CTO PCI attempt or treatment of more than one CTO lesion during the study period, each eligible procedure will be recorded as a separate procedural episode and linked to the same patient using a unique study identifier. No specific CTO PCI strategy, technique, device, or treatment will be assigned by the study protocol. All procedural and clinical decisions will be made by the treating physicians according to routine clinical practice.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of consecutive adult patients undergoing attempted PCI for coronary chronic total occlusion (CTO) at participating centers in Türkiye. Both successful and unsuccessful procedures will be included. Repeat CTO PCI attempts and procedures involving different CTO lesions in the same patient will be eligible. Each procedural episode will be recorded separately and linked to the same patient using a unique study identifier, allowing patient-level and procedure-level analyses.

You may qualify if:

• Age ≥18 years
• Presence of at least one coronary chronic total occlusion (CTO), defined as a coronary artery lesion with TIMI grade 0 antegrade flow and an estimated duration of occlusion of ≥3 months
• Undergoing an attempted PCI of the CTO at a participating center during the study period
• Provision of informed consent when required by the applicable ethics committee and local regulations

You may not qualify if:

• Age \<18 years
• Coronary lesion not meeting the predefined criteria for CTO
• No attempted CTO PCI during the procedure
• Inability or refusal to provide informed consent when informed consent is required
• Withdrawal of consent from participation in the registry

Sponsors & Collaborators

• Ahmet Seyfeddin Gürbüz: lead

Study Sites (6)

Dicle University, Faculty of Medicine

Diyarbakır, Turkey (Türkiye)

Location

Siyami Ersek Education and Research Hospital

Istanbul, Turkey (Türkiye)

Location

Acıbadem Kent Hospital

Izmir, Turkey (Türkiye)

Location

izmir katip celebi university, Ataturk Education and Research Hospital

Izmir, Turkey (Türkiye)

Location

Necmettin Erbakan University, Faculty of Medicine

Konya, 42020, Turkey (Türkiye)

Location

Inonu University, Faculty of Medicine

Malatya, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Ahmet S Gurbuz, Professor

  Necmettin Erbakan University, Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmet S Gurbuz, PROFESSOR

CONTACT

0905554971845; ahmetseyfeddingurbuz@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor of Cardiology

Study Record Dates

• First Submitted: August 2, 2026
• First Posted: August 12, 2026
• Study Start: July 24, 2026
• Primary Completion (Estimated): July 24, 2036
• Study Completion (Estimated): July 24, 2036
• Last Updated: August 12, 2026

Record last verified: 2026-08

Locations

TU (6)