NCT02061436

Brief Summary

Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to determine the frequency of CTO PCI performed at the participating sites and examine the procedural strategies utilized, and the procedural (both immediate and during follow-up) outcomes.

Trial Health

50
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2012

Longer than P75 for all trials

Geographic Reach
6 countries

48 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
2.1 years until next milestone

First Submitted

Initial submission to the registry

January 28, 2014

Completed
15 days until next milestone

First Posted

Study publicly available on registry

February 12, 2014

Completed
9.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2024

Completed
Last Updated

March 10, 2022

Status Verified

March 1, 2022

Enrollment Period

12 years

First QC Date

January 28, 2014

Last Update Submit

March 8, 2022

Conditions

Coronary Artery Disease

Keywords

chronic total occlusion, percutaneous coronary intervention

Outcome Measures

Primary Outcomes (1)

  • procedural success of chronic total occlusion PCI

    Procedural success is defined as achievement of technical success with no in-hospital major adverse cardiac events (MACE). In-hospital MACE includes any of the following adverse events prior to hospital discharge: death from any cause, Q-wave myocardial infarction, urgent repeat target vessel revascularization with PCI or coronary bypass surgery, tamponade requiring pericardiocentesis or surgery, or stroke.

    discharge from the hospital after PCI, which usually happens the day after the procedure

Secondary Outcomes (2)

  • technical success of chronic total occlusion PCI

    discharge from the hospital after PCI, which usually happens the day after the procedure

  • major adverse cardiovascular events

    discharge from the hospital after PCI (which usually happens the day after the procedure) and during clinically-indicated follow-up. There are no pre-specified follow-up time periods - patients are assessed if and when they come to receive clinical care.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients undergoing CTO PCI at each of the participating centers.

You may qualify if:

  • Patients undergoing CTO PCI at each of the participating centers.

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (48)

Banner Samaritan Health Center

Phoenix, Arizona, 85006, United States

COMPLETED

Little Rock VA Medical Center

Little Rock, Arkansas, 72205, United States

RECRUITING

San Diego VAMC and University of California

San Diego, California, 92161, United States

RECRUITING

Torrance Memorial Medical Center

Torrance, California, 90505, United States

ACTIVE NOT RECRUITING

Medical Center of the Rockies

Loveland, Colorado, 80538, United States

RECRUITING

Memorial Hospital

Jacksonville, Florida, 32216, United States

RECRUITING

Piedmont Heart Institute

Atlanta, Georgia, 30309, United States

ACTIVE NOT RECRUITING

Emory University Hospital- Emory Heart and Vascular Center

Atlanta, Georgia, 30322, United States

RECRUITING

Wellstar Health System

Marietta, Georgia, 30060, United States

RECRUITING

Northwestern Bluhm Cardiovascular Institute

Chicago, Illinois, 60611, United States

ACTIVE NOT RECRUITING

St. Vincent Heart Center

Indianapolis, Indiana, 46260, United States

RECRUITING

Tulane University Heart and Vascular Institute

New Orleans, Louisiana, 70112, United States

RECRUITING

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

RECRUITING

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

RECRUITING

Henry Ford Medical Center

Detroit, Michigan, 48202, United States

RECRUITING

Minneapolis Heart Institute

Minneapolis, Minnesota, 55407, United States

RECRUITING

Minneapolis VA Healthcare System and University of Minnesota

Minneapolis, Minnesota, 55417, United States

RECRUITING

Mid America Heart Institute

Kansas City, Missouri, 64131, United States

ACTIVE NOT RECRUITING

Maimonides Medical Center

Brooklyn, New York, 11219, United States

RECRUITING

Trinity Medical WNY

Buffalo, New York, 14221, United States

RECRUITING

Columbia University

New York, New York, 10032, United States

RECRUITING

Carolina East Medical Center

New Bern, North Carolina, 28560, United States

RECRUITING

The Christ Hospital Ohio Heart & Vascular

Cincinnati, Ohio, 45219, United States

RECRUITING

University Hospitals (UH) Case Western Reserve University

Cleveland, Ohio, 44106, United States

RECRUITING

Cleveland Clinic

Cleveland, Ohio, 44195, United States

RECRUITING

Kettering Health Network

Kettering, Ohio, 45429, United States

RECRUITING

Oklahoma City VA Medical Center

Oklahoma City, Oklahoma, 73117, United States

RECRUITING

Oklahoma Heart Institute at Hillcrest Medical Center

Tulsa, Oklahoma, 74104, United States

RECRUITING

Providence Heart & Vascular Institute

Portland, Oregon, 97225, United States

RECRUITING

University of Pittsburgh Medical Center Presbyterian

Pittsburgh, Pennsylvania, 15213, United States

RECRUITING

WellSpan Heart & Vascular

York, Pennsylvania, 17405, United States

RECRUITING

Tristar Centennial Medical Center

Nashville, Tennessee, 37203, United States

RECRUITING

University of Texas Southwestern Medical Center

Dallas, Texas, 75216, United States

RECRUITING

VA Dallas Medical Center

Dallas, Texas, 75216, United States

RECRUITING

Baylor Heart and Vascular Hospital

Dallas, Texas, 75226, United States

RECRUITING

Houston Methodist Hospital

Houston, Texas, 77030, United States

ACTIVE NOT RECRUITING

Baylor Scott & White Research Institute-The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States

RECRUITING

Baylor Scott and White Research Institute/ The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States

RECRUITING

The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States

RECRUITING

Providence Health Center

Waco, Texas, 76712, United States

ACTIVE NOT RECRUITING

Peacehealth Cardiology

Bellingham, Washington, 98225, United States

ACTIVE NOT RECRUITING

Appleton Cardiology

Appleton, Wisconsin, 54911, United States

COMPLETED

St. Boniface General Hospital

Winnipeg, Manitoba, R3E 0W3, Canada

RECRUITING

Aswan Heart Centre

Aswān, Egypt

RECRUITING

Korgialeneio-Benakeio Hellenic Red Cross General Hospital of Athens

Athens, Attica, 11526, Greece

RECRUITING

Henry Hunant Hospital Center

Athens, Greece

RECRUITING

St. George Hospital University Medical Center

Beirut, Lebanon

RECRUITING

Meshalkin Novosibirsk Research Institute

Novosibirsk, Novosibirsk Oblast, 630055, Russia

RECRUITING

Related Publications (46)

  • Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham JA, Michael TT, Patel VG, Rangan BV, Kotsia AP, Lembo N, Kandzari DE, Lee J, Kalynych A, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. Application of the "hybrid approach" to chronic total occlusions in patients with previous coronary artery bypass graft surgery (from a Contemporary Multicenter US registry). Am J Cardiol. 2014 Jun 15;113(12):1990-4. doi: 10.1016/j.amjcard.2014.03.039. Epub 2014 Mar 31.

    PMID: 24793678RESULT

  • Christopoulos G, Karmpaliotis D, Alaswad K, Lombardi WL, Grantham JA, Rangan BV, Kotsia AP, Lembo N, Kandzari DE, Lee J, Kalynych A, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. The efficacy of "hybrid" percutaneous coronary intervention in chronic total occlusions caused by in-stent restenosis: insights from a US multicenter registry. Catheter Cardiovasc Interv. 2014 Oct 1;84(4):646-51. doi: 10.1002/ccd.25465. Epub 2014 Jul 4.

    PMID: 24585508RESULT

  • Christopoulos G, Karmpaliotis D, Wyman MR, Alaswad K, McCabe J, Lombardi WL, Grantham JA, Marso SP, Kotsia AP, Rangan BV, Garcia SA, Lembo N, Kandzari D, Lee J, Kalynych A, Carlson H, Thompson CA, Banerjee S, Brilakis ES. Percutaneous intervention of circumflex chronic total occlusions is associated with worse procedural outcomes: insights from a Multicentre US Registry. Can J Cardiol. 2014 Dec;30(12):1588-94. doi: 10.1016/j.cjca.2014.07.007. Epub 2014 Jul 16.

    PMID: 25442459RESULT

  • Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham A, Patel VG, Rangan BV, Kotsia AP, Lembo N, Kandzari D, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. The efficacy and safety of the "hybrid" approach to coronary chronic total occlusions: insights from a contemporary multicenter US registry and comparison with prior studies. J Invasive Cardiol. 2014 Sep;26(9):427-32.

    PMID: 25198485RESULT

  • Sapontis J, Christopoulos G, Grantham JA, Wyman RM, Alaswad K, Karmpaliotis D, Lombardi WL, McCabe JM, Marso SP, Kotsia AP, Rangan BV, Christakopoulos GE, Garcia S, Thompson CA, Banerjee S, Brilakis ES. Procedural failure of chronic total occlusion percutaneous coronary intervention: Insights from a multicenter US registry. Catheter Cardiovasc Interv. 2015 Jun;85(7):1115-22. doi: 10.1002/ccd.25807. Epub 2015 Feb 3.

    PMID: 25557905RESULT

  • Christopoulos G, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi WL, Menon RV, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh M, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Tarar MN, Christakopoulos GE, Thompson CA, Banerjee S, Brilakis ES. Application and outcomes of a hybrid approach to chronic total occlusion percutaneous coronary intervention in a contemporary multicenter US registry. Int J Cardiol. 2015 Nov 1;198:222-8. doi: 10.1016/j.ijcard.2015.06.093. Epub 2015 Jun 27.

    PMID: 26189193RESULT

  • Christopoulos G, Wyman RM, Alaswad K, Karmpaliotis D, Lombardi W, Grantham JA, Yeh RW, Jaffer FA, Cipher DJ, Rangan BV, Christakopoulos GE, Kypreos MA, Lembo N, Kandzari D, Garcia S, Thompson CA, Banerjee S, Brilakis ES. Clinical Utility of the Japan-Chronic Total Occlusion Score in Coronary Chronic Total Occlusion Interventions: Results from a Multicenter Registry. Circ Cardiovasc Interv. 2015 Jul;8(7):e002171. doi: 10.1161/CIRCINTERVENTIONS.114.002171.

    PMID: 26162857RESULT

  • Alaswad K, Menon RV, Christopoulos G, Lombardi WL, Karmpaliotis D, Grantham JA, Marso SP, Wyman MR, Pokala NR, Patel SM, Kotsia AP, Rangan BV, Lembo N, Kandzari D, Lee J, Kalynych A, Carlson H, Garcia SA, Thompson CA, Banerjee S, Brilakis ES. Transradial approach for coronary chronic total occlusion interventions: Insights from a contemporary multicenter registry. Catheter Cardiovasc Interv. 2015 Jun;85(7):1123-9. doi: 10.1002/ccd.25827. Epub 2015 Feb 3.

    PMID: 25640902RESULT

  • Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Patel M, Bahadorani J, Lombardi WL, Wyman MR, Grantham JA, Doing A, Moses JW, Kirtane A, Parikh M, Ali ZA, Kalra S, Kandzari DE, Lembo N, Garcia S, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. Use of antegrade dissection re-entry in coronary chronic total occlusion percutaneous coronary intervention in a contemporary multicenter registry. Int J Cardiol. 2016 Jul 1;214:428-37. doi: 10.1016/j.ijcard.2016.03.215. Epub 2016 Apr 6.

    PMID: 27088405RESULT

  • Karacsonyi J, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman MR, Lombardi WL, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh MA, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Martinez Parachini JR, Resendes E, Rangan BV, Ungi I, Thompson CA, Banerjee S, Brilakis ES. Effect of Previous Failure on Subsequent Procedural Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention (from a Contemporary Multicenter Registry). Am J Cardiol. 2016 Apr 15;117(8):1267-71. doi: 10.1016/j.amjcard.2016.01.021. Epub 2016 Jan 28.

    PMID: 26899493RESULT

  • Nguyen-Trong PK, Rangan BV, Karatasakis A, Danek BA, Christakopoulos GE, Martinez-Parachini JR, Resendes E, Ayers CR, Luna M, Abdullah S, Kumbhani DJ, Addo T, Grodin J, Banerjee S, Brilakis ES. Predictors and Outcomes of Side-Branch Occlusion in Coronary Chronic Total Occlusion Interventions. J Invasive Cardiol. 2016 Apr;28(4):168-73. Epub 2016 Jan 15.

    PMID: 26773239RESULT

  • Christopoulos G, Kandzari DE, Yeh RW, Jaffer FA, Karmpaliotis D, Wyman MR, Alaswad K, Lombardi W, Grantham JA, Moses J, Christakopoulos G, Tarar MNJ, Rangan BV, Lembo N, Garcia S, Cipher D, Thompson CA, Banerjee S, Brilakis ES. Development and Validation of a Novel Scoring System for Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Interventions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Score. JACC Cardiovasc Interv. 2016 Jan 11;9(1):1-9. doi: 10.1016/j.jcin.2015.09.022.

    PMID: 26762904RESULT

  • Karatasakis A, Tarar MN, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi WL, Grantham JA, Kandzari DE, Lembo NJ, Moses JW, Kirtane AJ, Parikh M, Garcia S, Doing A, Pershad A, Shah A, Patel M, Bahadorani J, Shoultz CA Jr, Danek BA, Thompson CA, Banerjee S, Brilakis ES. Guidewire and microcatheter utilization patterns during antegrade wire escalation in chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry. Catheter Cardiovasc Interv. 2017 Mar 1;89(4):E90-E98. doi: 10.1002/ccd.26568. Epub 2016 May 17.

    PMID: 27184465RESULT

  • Christakopoulos GE, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi W, Grantham JA, Kandzari DA, Lembo N, Moses JW, Kirtane A, Parikh M, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Christopoulos G, Karatasakis A, Thompson CA, Banerjee S, Brilakis ES. Contrast Utilization During Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Contemporary Multicenter Registry. J Invasive Cardiol. 2016 Jul;28(7):288-94.

    PMID: 27342206RESULT

  • Nguyen-Trong PK, Alaswad K, Karmpaliotis D, Lombardi W, Grantham JA, Lembo N, Kandzari D, Karatasakis A, Karacsonyi J, Danek BA, Rangan BV, Roesle M, Ayers CR, Thompson CA, Banerjee S, Brilakis ES. Use of Saphenous Vein Bypass Grafts for Retrograde Recanalization of Coronary Chronic Total Occlusions: Insights From a Multicenter Registry. J Invasive Cardiol. 2016 Jun;28(6):218-24.

    PMID: 27236005RESULT

  • Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel MP, Bahadorani J, Lombardi WL, Wyman RM, Grantham JA, Kandzari DE, Lembo NJ, Doing AH, Toma C, Moses JW, Kirtane AJ, Ali ZA, Parikh M, Garcia S, Nguyen-Trong PK, Karacsonyi J, Alame AJ, Kalsaria P, Thompson C, Banerjee S, Brilakis ES. Effect of Lesion Age on Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Contemporary US Multicenter Registry. Can J Cardiol. 2016 Dec;32(12):1433-1439. doi: 10.1016/j.cjca.2016.04.007. Epub 2016 Apr 22.

    PMID: 27476986RESULT

  • Karmpaliotis D, Karatasakis A, Alaswad K, Jaffer FA, Yeh RW, Wyman RM, Lombardi WL, Grantham JA, Kandzari DE, Lembo NJ, Doing A, Patel M, Bahadorani JN, Moses JW, Kirtane AJ, Parikh M, Ali ZA, Kalra S, Nguyen-Trong PK, Danek BA, Karacsonyi J, Rangan BV, Roesle MK, Thompson CA, Banerjee S, Brilakis ES. Outcomes With the Use of the Retrograde Approach for Coronary Chronic Total Occlusion Interventions in a Contemporary Multicenter US Registry. Circ Cardiovasc Interv. 2016 Jun;9(6):10.1161/CIRCINTERVENTIONS.115.003434 e003434. doi: 10.1161/CIRCINTERVENTIONS.115.003434.

    PMID: 27307562RESULT

  • Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel MP, Bahadorani JN, Wyman RM, Lombardi WL, Grantham JA, Kandzari DE, Lembo NJ, Doing AH, Moses JW, Kirtane AJ, Garcia S, Parikh MA, Ali ZA, Karacsonyi J, Kalra S, Rangan BV, Kalsaria P, Thompson CA, Banerjee S, Brilakis ES. Impact of Proximal Cap Ambiguity on Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Multicenter US Registry. J Invasive Cardiol. 2016 Oct;28(10):391-396.

    PMID: 27705889RESULT

  • Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel MP, Bahadorani JN, Lombardi WL, Wyman RM, Grantham JA, Kandzari DE, Lembo NJ, Doing AH, Toma C, Moses JW, Kirtane AJ, Ali Z, Parikh M, Garcia S, Danek BA, Karacsonyi J, Alame A, Kalsaria P, Thompson C, Banerjee S, Brilakis ES. Approaches to percutaneous coronary intervention of right coronary artery chronic total occlusions: insights from a multicentre US registry. EuroIntervention. 2016 Dec 10;12(11):e1326-e1335. doi: 10.4244/EIJ-D-16-00265.

    PMID: 27934609RESULT

  • Karacsonyi J, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani J, Doing A, Ali ZA, Karatasakis A, Danek BA, Rangan BV, Alame AJ, Banerjee S, Brilakis ES. Prevalence, indications and management of balloon uncrossable chronic total occlusions: Insights from a contemporary multicenter US registry. Catheter Cardiovasc Interv. 2017 Jul;90(1):12-20. doi: 10.1002/ccd.26780. Epub 2016 Sep 21.

    PMID: 27650935RESULT

  • Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani JN, Lombardi WL, Wyman RM, Grantham JA, Kandzari DE, Lembo NJ, Doing AH, Toma C, Moses JW, Kirtane AJ, Parikh MA, Ali ZA, Garcia S, Kalsaria P, Karacsonyi J, Alame AJ, Thompson CA, Banerjee S, Brilakis ES. Comparison of various scores for predicting success of chronic total occlusion percutaneous coronary intervention. Int J Cardiol. 2016 Dec 1;224:50-56. doi: 10.1016/j.ijcard.2016.08.317. Epub 2016 Aug 23.

    PMID: 27611917RESULT

  • Martinez-Parachini JR, Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani J, Doing A, Nguyen-Trong PK, Danek BA, Karacsonyi J, Alame A, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions: insights from a US multicentre registry. Diabet Med. 2017 Apr;34(4):558-562. doi: 10.1111/dme.13272. Epub 2016 Nov 3.

    PMID: 27743404RESULT

  • Karatasakis A, Iwnetu R, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Kandzari DE, Lembo NJ, Patel M, Mahmud E, Lombardi WL, Wyman RM, Grantham JA, Doing AH, Toma C, Choi JW, Uretsky BF, Moses JW, Kirtane AJ, Ali ZA, Parikh M, Karacsonyi J, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. The Impact of Age and Sex on In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention. J Invasive Cardiol. 2017 Apr;29(4):116-122. Epub 2017 Jan 15.

    PMID: 28089997RESULT

  • Garcia S, Alraies MC, Karatasakis A, Yannopoulos D, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel MP, Bahadorani J, Karacsonyi J, Kalsaria P, Danek B, Banerjee S, Brilakis ES. Coronary artery spatial distribution of chronic total occlusions: Insights from a large US registry. Catheter Cardiovasc Interv. 2017 Jul;90(1):23-30. doi: 10.1002/ccd.26844. Epub 2016 Nov 10.

    PMID: 27860111RESULT

  • Christakopoulos GE, Christopoulos G, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman MR, Lombardi WL, Tarar MN, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh M, Green P, Finn M, Garcia S, Doing AH, Hatem R, Thompson CA, Banerjee S, Brilakis ES. Predictors of Excess Patient Radiation Exposure During Chronic Total Occlusion Coronary Intervention: Insights From a Contemporary Multicentre Registry. Can J Cardiol. 2017 Apr;33(4):478-484. doi: 10.1016/j.cjca.2016.11.002. Epub 2016 Nov 11.

    PMID: 28169091RESULT

  • Mutlu D, Strepkos D, Ser OS, Carvalho PEP, Alexandrou M, Jalli S, Azzalini L, Ybarra L, Alaswad K, Jaffer FA, Davies R, Rangan BV, Sandoval Y, Nicholas Burke M, Gorgulu S, Brilakis ES; PROGRESS-CTO Investigators. Traditional Versus Dual Lumen Microcatheter-Assisted Parallel Wiring in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry. Catheter Cardiovasc Interv. 2025 May;105(6):1493-1501. doi: 10.1002/ccd.31472. Epub 2025 Mar 10.

    PMID: 40065565DERIVED

  • Mutlu D, Strepkos D, Carvalho PE, Alexandrou M, Al-Ogaili A, Jalli S, Alaswad K, Jaffer FA, Davies R, Poommipanit P, Frizzel J, Elbarouni B, Khatri JJ, Gorgulu S, Goktekin O, Ozdemir R, Uluganyan M, ElGuindy A, Sadek Y, Ahmed Y, Basir MB, Raj L, Ybarra L, Murad B, Rangan BV, Mastrodemos OC, Azzalini L, Sandoval Y, Burke MN, Brilakis ES. Use of the Ostial Flash balloon in aorto-ostial chronic total occlusion percutaneous coronary intervention. J Invasive Cardiol. 2025 May;37(5). doi: 10.25270/jic/24.00263.

    PMID: 39808454DERIVED

  • Rempakos A, Alexandrou M, Mutlu D, Choi JW, Poommipanit P, Khatri JJ, Young L, Jefferson B, Gorgulu S, Jaffer FA, Chandwaney R, Davies R, Benton S, Alaswad K, Azzalini L, Kearney KE, Krestyaninov O, Khelimskii D, Dattilo P, Reddy N, Abi-Rafeh N, Elguindy A, Goktekin O, Rangan BV, Mastrodemos OC, Al-Ogaili A, Sandoval Y, Burke NM, Brilakis ES, Basir MB. Validation of the BCIS CHIP Score in chronic total occlusion percutaneous coronary intervention. Catheter Cardiovasc Interv. 2024 May;103(6):856-862. doi: 10.1002/ccd.31045. Epub 2024 Apr 17.

    PMID: 38629740DERIVED

  • Al-Ogaili A, Alexandrou M, Rempakos A, Mutlu D, Choi JW, Poommipanit P, Khatri JJ, Alaswad K, Basir MB, Chandwaney RH, Gorgulu S, ElGuindy AM, Elbarouni B, Jaber W, Rinfret S, Nicholson W, Jaffer FA, Aygul N, Azzalini L, Kearney KE, Frizzell J, Davies R, Goktekin O, Rangan BV, Mastrodemos OC, Sandoval Y, Nicholas Burke M, Brilakis ES. Retrograde chronic total occlusion percutaneous coronary intervention via ipsilateral collaterals. Catheter Cardiovasc Interv. 2024 May;103(6):863-872. doi: 10.1002/ccd.31019. Epub 2024 Apr 2.

    PMID: 38563074DERIVED

  • Rempakos A, Alexandrou M, Mutlu D, Choi JW, Poommipanit P, Khatri JJ, Young L, Dattilo P, Sadek Y, Davies R, Gorgulu S, Jaffer FA, Chandwaney R, Jefferson B, Elbarouni B, Azzalini L, Kearney KE, Alaswad K, Basir MB, Krestyaninov O, Khelimskii D, Aygul N, Abi-Rafeh N, Elguindy A, Goktekin O, Rangan BV, Mastrodemos OC, Al-Ogaili A, Sandoval Y, Burke MN, Brilakis ES, Kalyanasundaram A. Predictors of successful primary antegrade wiring in chronic total occlusion percutaneous coronary intervention. J Invasive Cardiol. 2024 Jun;36(6). doi: 10.25270/jic/23.00305.

    PMID: 38446022DERIVED

  • Mutlu D, Rempakos A, Alexandrou M, Al-Ogaili A, Rangan BV, Mastrodemos OC, Sandoval Y, Burke MN, Brilakis ES. Radiation dose during contemporary percutaneous coronary interventions for chronic total occlusion: insights from the PROGRESS-CTO registry. J Invasive Cardiol. 2024 Apr;36(4). doi: 10.25270/jic/23.00281.

    PMID: 38412437DERIVED

  • Simsek B, Rempakos A, Kostantinis S, Karacsonyi J, Rinfret S, Jaber W, Nicholson W, Gorgulu S, Alaswad K, Khatri J, Poommipanit P, Aygul N, Krestyanino O, Khelimskii D, Uretsky B, Goktekin O, Dattilo P, Potluri S, Al-Azizi K, Mastrodemos OC, Rangan BV, Allana SS, Sandoval Y, Burke MN, Brilakis ES. Frequency and outcomes of ad hoc chronic total occlusion percutaneous coronary intervention: insights from the progress-cto registry. J Invasive Cardiol. 2023 Jul;35(7):E329-E340. doi: 10.25270/jic/23.00070.

    PMID: 37769619DERIVED

  • Simsek B, Rempakos A, Kostantinis S, Karacsonyi J, Gorgulu S, Alaswad K, Choi JW, Jaffer FA, Doshi D, Poommipanit P, Aygul N, Krestyaninov O, Khelimskii D, Uretsky B, Davies R, Goktekin O, ElGuindy A, Jefferson BK, Patel TN, Patel M, Sheikh A, Karmpaliotis D, Potluri S, Al-Azizi K, Mastrodemos OC, Rangan BV, Allana SS, Sandoval Y, Burke MN, Brilakis ES. Periprocedural Mortality in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry. Circ Cardiovasc Interv. 2023 Jun;16(6):e012977. doi: 10.1161/CIRCINTERVENTIONS.123.012977. Epub 2023 Jun 1.

    PMID: 37259859DERIVED

  • Simsek B, Khatri J, Young L, Kostantinis S, Karacsonyi J, Rempakos A, Alaswad K, Jaffer FA, Doshi D, Gorgulu S, Goktekin O, Kerrigan J, Haddad EV, Rinfret S, Jaber WA, Nicholson W, Krestyaninov O, Khelimskii D, Choi JW, Patel TN, Jefferson BK, Bradley SM, Rao SV, Rangan BV, Allana SS, Sandoval Y, Burke MN, Brilakis ES, Poommipanit PB; PROGRESS-CTO investigators. Same day discharge versus overnight observation following chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS-CTO registry. Catheter Cardiovasc Interv. 2023 May;101(6):1028-1035. doi: 10.1002/ccd.30644. Epub 2023 Mar 24.

    PMID: 36960766DERIVED

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    PMID: 36525540DERIVED

  • Simsek B, Kostantinis S, Karacsonyi J, Alaswad K, Karmpaliotis D, Masoumi A, Jaffer FA, Doshi D, Khatri J, Poommipanit P, Gorgulu S, Abi Rafeh N, Goktekin O, Krestyaninov O, Davies R, ElGuindy A, Haddad EV, Kerrigan J, Patel M, Chandwaney RH, Mastrodemos OC, Allana S, Rangan BV, Brilakis ES. Predictors of success in primary retrograde strategy in chronic total occlusion percutaneous coronary intervention: insights from the PROGRESS-chronic total occlusion registry. Catheter Cardiovasc Interv. 2022 Jul;100(1):19-27. doi: 10.1002/ccd.30228. Epub 2022 May 26.

    PMID: 35615875DERIVED

  • Simsek B, Kostantinis S, Karacsonyi J, Alaswad K, Karmpaliotis D, Masoumi A, Jaffer FA, Doshi D, Khatri J, Poommipanit P, Gorgulu S, Abi Rafeh N, Goktekin O, Krestyaninov O, Davies R, ElGuindy A, Jefferson BK, Patel TN, Patel M, Chandwaney RH, Mastrodemos OC, Rangan BV, Brilakis ES. Prevalence and outcomes of balloon undilatable chronic total occlusions: Insights from the PROGRESS-CTO. Int J Cardiol. 2022 Sep 1;362:42-46. doi: 10.1016/j.ijcard.2022.04.057. Epub 2022 Apr 26.

    PMID: 35483480DERIVED

  • Vemmou E, Alaswad K, Khatri JJ, Nikolakopoulos I, Karacsonyi J, Xenogiannis I, Karmpaliotis D, Garcia S, Burke MN, Brilakis ES. Patient Radiation Dose During Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry. Circ Cardiovasc Interv. 2020 Oct;13(10):e009412. doi: 10.1161/CIRCINTERVENTIONS.120.009412. Epub 2020 Sep 25. No abstract available.

    PMID: 32972204DERIVED

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    PMID: 31638578DERIVED

  • Tajti P, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Choi JW, Burke MN, Doing AH, Dattilo P, Toma C, Smith AJC, Uretsky B, Holper E, Potluri S, Wyman RM, Kandzari DE, Garcia S, Krestyaninov O, Khelimskii D, Koutouzis M, Tsiafoutis I, Jaber W, Samady H, Moses JW, Lembo NJ, Parikh M, Kirtane AJ, Ali ZA, Doshi D, Xenogiannis I, Stanberry LI, Rangan BV, Ungi I, Banerjee S, Brilakis ES. In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions in Patients With Prior Coronary Artery Bypass Graft Surgery. Circ Cardiovasc Interv. 2019 Mar;12(3):e007338. doi: 10.1161/CIRCINTERVENTIONS.118.007338.

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Related Links

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • Emmanouil S Brilakis, MD, PhD

    Minneapolis Heart Institute Foundation

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Emmanouil S Brilakis, MD, PhD

CONTACT

(214) 857-1547esbrilakis@gmail.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Year
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 28, 2014

First Posted

February 12, 2014

Study Start

January 1, 2012

Primary Completion

January 1, 2024

Study Completion

January 1, 2024

Last Updated

March 10, 2022

Record last verified: 2022-03

Locations

RU(1)LE(1)US(42)EG(1)CA(1)GR(2)