NCT07758543

Brief Summary

Bell's palsy is an acute,unilateral facial paresis that significantly affects patient's facial symmetry,motor function and quality of life.The primary goal of this randomized controlled trial is to determine if integrating the targeted neural mobilization with proprioceptive neuromuscular facilitation improves facial symmetry and motor function more effectively than using pnf alone.participants allocated to either experimental group receiving neural mobilization and pnf or control group receiving pnf alone.after approval from ERC FUSH, participants are assessed using housebrackman scale and sunnybrook facial grading system(scales to asses the degree of severity of facial paralysis) at first and fourth week of intervention application.data will be analysed using spss v.22.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
38

participants targeted

Target at P25-P50 for not_applicable

Timeline
5mo left

Started Sep 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress69%
Sep 2025Jan 2027

Study Start

First participant enrolled

September 14, 2025

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

August 6, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 11, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 10, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 10, 2027

Last Updated

August 11, 2026

Status Verified

August 1, 2026

Enrollment Period

1.2 years

First QC Date

August 6, 2026

Last Update Submit

August 6, 2026

Conditions

Keywords

Bell's palsyfacial paralysisneural mobilizationproprioceptive neuromuscular facilitation

Outcome Measures

Primary Outcomes (2)

  • Resting symmetry

    It is measured by sunny brook facial grading system(SFGS) SFGS Score= {Voluntary Movement Score} - {Synkinesis Score} - {Resting Symmetry Score} * Maximum score = 100 (Normal facial function) * Minimum score = 0 (Complete paralysis).

    4 weeks

  • Severity of facial paralysis

    It is measured by Housebrackman scale Patients graded IV-VI show severe impairment Patients graded I-III have mild-to-moderate dysfunction

    4 weeks

Study Arms (2)

pnf and neural mobilization

EXPERIMENTAL

1. Gentle facial nerve mobilization applied within pain free range (10-12 min/session, 6-10 repetition/technique,30-60 seconds/glide). 2. rhythmic initiation and resisted voluntary movements(3-5 rep/movement, 3-4 sets /session)

Procedure: GROUP A COMBINED THERAPY GROUP

pnf alone

ACTIVE COMPARATOR

Rhythmic initiation and resisted voluntary movements(3-5 rep/movement, 3-4 sets /session).

Procedure: GROUP B PNF GROUP

Interventions

Receives proprioceptive neuromuscular facilitation (pnf), neural mobilization and conventional therapy. DESCRIPTION * PNF using rhythmic initiation and resisted voluntary movements directed at the frontalis, orbicularis oculi, zygomaticus major and minor, orbicularis oris and buccinator; three to five repetitions per pattern, three to four sets per session. Progression governed as tolerated with resistance and repetitions increased as recovery allowed. * Gentle facial nerve mobilization within a pain-free range, ten to twelve minutes per session; six to ten repetitions per technique or thirty to sixty seconds per glide, advancing glide range as tolerated. * Conventional therapy; clinic-based facial expression exercises with interrupted galvanic stimulation (rectangular waveform, 100 ms, 3 sets × 30 contractions), 2-3 sessions weekly, 15-20 minutes; plus daily home facial exercises with mirror feedback (smiling, blinking, puckering), 10-15 minutes.

pnf and neural mobilization

Receives proprioceptive neuromuscular facilitation and conventional therapy. DESCRIPTION * Proprioceptive neuromuscular facilitation, using rhythmic initiation and resisted voluntary movements. Progression governed by the participant's tolerance and motor control, with resistance and repetitions increased as recovery allowed. * Conventional therapy: clinic-based facial expression exercises with interrupted galvanic stimulation (rectangular waveform, 100 ms, 3 sets × 30 contractions), 2-3 sessions weekly, 15-20 minutes; plus daily home facial exercises with mirror feedback (smiling, blinking, puckering), 10-15 minutes.

pnf alone

Eligibility Criteria

Age15 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Age 15-60 years.
  • Both male and female.
  • Patient diagnosed with bells palsy by neurologist or relevant specialist.
  • Patients with moderate to severe Bell's palsy evaluated by Modified House-Brackman SCALE
  • Patient without exposure to any other rehabilitation program
  • Patients within the acute or subacute phases (within 6 months of onset)

You may not qualify if:

  • Patients with a history of recurrent Bell's palsy or other neurological disorders (e.g., stroke, multiple sclerosis)
  • Patients with pacemakers, metal implants or other contraindications for electrical muscle stimulation.
  • Presence of facial trauma or surgical interventions that might interfere with rehabilitation outcomes.
  • Co-existing medical conditions (e.g., diabetes mellitus, infections, or malignancies) that might impair nerve recovery or affect study outcomes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Foundation University College of Physical Therapy

Islamabad, 44000, Pakistan

RECRUITING

MeSH Terms

Conditions

Bell PalsyFacial ParalysisFacial Asymmetry

Condition Hierarchy (Ancestors)

Herpesviridae InfectionsDNA Virus InfectionsVirus DiseasesInfectionsMouth DiseasesStomatognathic DiseasesFacial Nerve DiseasesCranial Nerve DiseasesNervous System DiseasesParalysisNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsPathological Conditions, Anatomical

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 6, 2026

First Posted

August 11, 2026

Study Start

September 14, 2025

Primary Completion (Estimated)

December 10, 2026

Study Completion (Estimated)

January 10, 2027

Last Updated

August 11, 2026

Record last verified: 2026-08

Locations