GNRI and Rectus Femoris Muscle Thickness in Older Patients Undergoing Hip Fracture Surgery

NCT07751692 | Not Yet Recruiting

• 2 other identifiers: FSMTRH-GNRI2026/07-41
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study will evaluate whether nutritional risk and reduced muscle mass are associated with postoperative outcomes in adults aged 65 years or older undergoing surgery for hip fracture. Nutritional risk will be assessed using the Geriatric Nutritional Risk Index (GNRI), which is calculated from routine preoperative serum albumin, body weight, and ideal body weight. Rectus femoris muscle thickness will be measured before surgery using a brief, noninvasive ultrasound examination of the non-fractured thigh. Participants will receive routine clinical care, and no treatment or anesthesia method will be assigned by the study. Clinical information will be collected from hospital records, including postoperative length of hospital stay, surgical site infection, and mortality. Survival status will be evaluated at 30 and 90 days after surgery using hospital records and/or telephone follow-up.

Conditions

Hip Fracture; Malnutrition; Sarcopenia; Postoperative Complications

Keywords

Geriatric Nutritional Risk Index; Rectus Femoris Muscle Thickness; Muscle Ultrasound; Geriatric Hip Fracture; Nutritional Risk; Postoperative Length of Stay; Surgical Site Infection; Prognostic Factors; 30-Day Mortality; 90-Day Mortality

Outcome Measures

Primary Outcomes (1)

• Number of Participants With Prolonged Postoperative Hospital Stay

  Postoperative hospital length of stay will be calculated as the number of days from the date of surgery to the date of discharge. Prolonged postoperative hospital stay will be defined as a length of stay exceeding the 75th percentile of the postoperative length-of-stay distribution in the completed study cohort. The outcome will be reported as the number and percentage of participants meeting this criterion.

  From the date of surgery through discharge from the index hospitalization, assessed up to 30 days after surgery.

Secondary Outcomes (3)

• Number of Participants With Surgical Site Infection

  From the date of surgery through 90 days after surgery

• Number of Participants With 30-Day All-Cause Mortality

  within 30 days after surgery

• Number of Participants With 90-Day All-Cause Mortality

  Within 90 days after surgery

Study Arms (1)

Geriatric Hip Fracture Cohort

Patients aged 65 years or older undergoing surgical treatment for hip fracture. Preoperative nutritional risk will be assessed using the Geriatric Nutritional Risk Index, and rectus femoris muscle thickness will be measured by ultrasound on the non-fractured side. Participants will receive routine clinical care, and no treatment, anesthesia technique, or surgical intervention will be assigned by the study.

Other: Geriatric Nutritional Risk Index Assessment

Interventions

Geriatric Nutritional Risk Index Assessment OTHER

Preoperative nutritional risk will be assessed using the Geriatric Nutritional Risk Index (GNRI), calculated from routine serum albumin, current body weight, and ideal body weight. Participants will be categorized as having no nutritional risk (GNRI greater than 98), low nutritional risk (GNRI 92 to 98), or moderate/severe nutritional risk (GNRI less than 92). The assessment will not alter routine clinical care.

Geriatric Hip Fracture Cohort

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of consecutive patients aged 65 years or older who are admitted to Fatih Sultan Mehmet Training and Research Hospital with a hip fracture and are scheduled to undergo surgical treatment. Eligible participants of both sexes will be enrolled after informed consent is obtained. Participants will receive routine perioperative clinical care without any treatment allocation by the study.

You may qualify if:

• Age 65 years or older
• Scheduled to undergo surgical treatment for hip fracture
• Provision of informed consent by the participant or, when applicable, a legally authorized representative

You may not qualify if:

• Pathological fracture or fracture related to malignancy
• Advanced neuromuscular disease
• Active infection
• Planned revision surgery
• Lower limb amputation or severe deformity preventing rectus femoris muscle thickness measurement
• Inability to obtain informed consent from the participant or a legally authorized representative

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital

Istanbul, 34000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hip Fractures; Malnutrition; Sarcopenia; Postoperative Complications; Surgical Wound Infection

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Nutrition Disorders; Nutritional and Metabolic Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Pathologic Processes; Wound Infection; Infections

Central Study Contacts

Öznur Demiroluk, MD

CONTACT

+905335229508; onrdemiroluk@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: August 3, 2026
• First Posted: August 7, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): May 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: August 7, 2026

Record last verified: 2026-08

Locations

TU (1)