Comparison of Three Analgesic Strategies for Hip Fracture Surgery

NCT07676734 | Not Yet Recruiting

• 2 other identifiers: HIP-QIPB-SIFIB-2026105
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Hip fracture surgery is associated with significant postoperative pain and increased opioid requirements. Regional anesthesia techniques may improve analgesia and reduce opioid consumption. This prospective, randomized, double-blind, controlled trial aims to compare the postoperative analgesic efficacy of Quadro-Iliac Plane Block (QIPB), Suprainguinal Fascia Iliaca Block (SIFIB), and standard analgesia in patients undergoing hip fracture surgery under spinal anesthesia. The primary outcome is cumulative tramadol consumption during the first 24 postoperative hours. Secondary outcome measures include postoperative pain intensity, rescue analgesic requirement, incidence of postoperative nausea and vomiting, Quality of Recovery-15 (QoR-15) score, and patient satisfaction score.

Conditions

Hip Fracture

Keywords

Quadro-Iliac Plane Block; Suprainguinal Fascia Iliaca Block; Regional Anesthesia; Postoperative Analgesia; Spinal Anesthesia; Tramadol Consumption; QoR-15; Hip Fracture Surgery

Outcome Measures

Primary Outcomes (1)

• Cumulative Tramadol Consumption During the First 24 Postoperative Hours

  The total amount of tramadol administered during the first 24 postoperative hours will be recorded and compared among the study groups.

  24 hours after surgery

Secondary Outcomes (7)

• Postoperative Pain Intensity at Rest

  At 0, 2, 6, 12, and 24 hours after surgery

• Time to First Rescue Analgesia

  Within the first 24 hours after surgery

• Rescue Analgesic Requirement

  Within the first 24 hours after surgery

• Incidence of Postoperative Nausea and Vomiting

  Within the first 24 hours after surgery

• Quality of Recovery-15 (QoR-15) Score

  24 hours after surgery

Study Arms (3)

Quadro-Iliac Plane Block Group

EXPERIMENTAL

Patients assigned to this group will receive ultrasound-guided quadro-iliac plane block in addition to standard multimodal analgesia following hip fracture surgery performed under spinal anesthesia.

Procedure: Quadro-Iliac Plane Block

Suprainguinal Fascia Iliaca Block Group

EXPERIMENTAL

Patients assigned to this group will receive ultrasound-guided suprainguinal fascia iliaca block in addition to standard multimodal analgesia following hip fracture surgery performed under spinal anesthesia.

Procedure: Suprainguinal Fascia Iliaca Block

Standard Analgesia Group

ACTIVE COMPARATOR

Patients assigned to this group will receive standard multimodal analgesia without a regional block following hip fracture surgery performed under spinal anesthesia.

Other: Standard Multimodal Analgesia

Interventions

Quadro-Iliac Plane Block PROCEDURE

Ultrasound-guided quadro-iliac plane block will be performed following spinal anesthesia in patients undergoing hip fracture surgery. The block will be administered in addition to standard multimodal analgesia.

Quadro-Iliac Plane Block Group

Suprainguinal Fascia Iliaca Block PROCEDURE

Ultrasound-guided suprainguinal fascia iliaca block will be performed following spinal anesthesia in patients undergoing hip fracture surgery. The block will be administered in addition to standard multimodal analgesia.

Suprainguinal Fascia Iliaca Block Group

Standard Multimodal Analgesia OTHER

Patients assigned to the control group will receive standard multimodal analgesia without a regional block following hip fracture surgery performed under spinal anesthesia.

Standard Analgesia Group

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients aged 18 years or older
• Patients scheduled for hip fracture surgery under spinal anesthesia
• American Society of Anesthesiologists (ASA) physical status I-III
• Provision of written informed consent

You may not qualify if:

• Refusal to participate
• Contraindications to spinal anesthesia
• Contraindications to regional anesthesia
• Allergy to local anesthetics or study medications
• Infection at the injection site
• Coagulopathy or anticoagulant therapy precluding regional block
• Cognitive impairment preventing pain assessment
• Chronic opioid use
• Revision surgery

Sponsors & Collaborators

• Başakşehir Çam & Sakura City Hospital: lead

Study Sites (1)

Başakşehir Çam and Sakura City Hospital

Istanbul, Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hip Fractures

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries

Study Officials

• Kenan Kart

  Karabuk University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

muzaffer Gencer

CONTACT

+905059436459; dr.m.gencer07@gmail.com

kenan kart, md

CONTACT

5063849983; kenankart@karabuk.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Participants, outcome assessors, and investigators involved in postoperative data collection and statistical analysis will be blinded to group allocation. The anesthesiologist performing the block procedures will not participate in postoperative assessments or data analysis.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Model Details: Participants will be randomly assigned in a 1:1:1 ratio to receive quadro-iliac plane block, suprainguinal fascia iliaca block, or standard analgesia.

Study Record Dates

• First Submitted: June 23, 2026
• First Posted: June 30, 2026
• Study Start: July 15, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: June 30, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)