Effect of Intraoperative Dexmedetomidine on Postoperative Pain in Elderly Patients Undergoing Major Abdominal Surgery: a Secondary Analysis Based on Prospective Data

NCT07744308 | Completed

• 1 other identifier: PLAGH S2025-917-01
• Study Type: observational
• Target: 2,754
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a secondary analysis of multicenter prospective data, including elderly patients who underwent elective major abdominal surgery between April 2020 and April 2022 from a perioperative database of elderly patients in China. This study aims to evaluate the impact of intraoperative dexmedetomidine on chronic postoperative pain in elderly patients undergoing major abdominal surgery, with a comprehensive analysis of pain across multiple dimensions.

Conditions

Chronic Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• The incidence of postoperative pain severity three months after the operation

  The incidence of postoperative pain severity three months after the operation using the Brief Pain Inventory (BPI). The BPI assesses pain at its "worst," "least," "average," and "now" (current pain). The scores of these four items are summed up and averaged. Then, this average value is multiplied by 10 to convert it into a standard score ranging from 0 to 100. The incidence of chronic postoperative pain is defined as a score of ≥ 10 after conversion (that is, the original average score is ≥ 1).

  Three months after the operation

Secondary Outcomes (5)

• The incidence of postoperative pain interference three months after the operation

  Three months after the operation

• Pain severity score

  Three months after the operation

• Pain interference score

  Three months after the operation

• EQ-5D-5L

  At 7 days, 1 month and 3 months after the surgery

• EQ VAS

  At 7 days, 1 month and 3 months after the surgery

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study is a secondary analysis based on a multi-center prospective database. We included 2,754 elderly patients who underwent major abdominal surgeries at five medical centers from April 2020 to April 2022. The data were sourced from Perioperative Database of Elderly Patients in China, which is a multi-center prospective study. The main objective of this parent study is to identify the perioperative risk factors for elderly non-cardiac surgery patients and establish a targeted risk prevention and management plan.

You may qualify if:

• Age ≥ 65 years;
• Underwent elective gastrointestinal and hepatobiliary surgeries.

You may not qualify if:

• Patients with ASA grade IV or above;
• Patients with missing exposure factor data;
• Patients without postoperative pain assessment data;
• Patients transferred to the ICU after surgery or who died within 7 days after surgery.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

Department of Anesthesiology, First Medical Center of the People's Liberation Army General Hospital, Beijing, Haidian 100853

Beijing, China

Location

Related Publications (3)

• Zeng M, Xu X, Li R, Zhang X, Ma T, Cui Q, Wang J, Li S, Peng Y. Dexmedetomidine Prevents Chronic Incisional Pain After Brain Tumor Resection: A Secondary Analysis of the Randomized Control Trial. Anesth Analg. 2024 Apr 1;138(4):839-847. doi: 10.1213/ANE.0000000000006563. Epub 2023 Jun 12.

  PMID: 37307232 RESULT

• Maurice-Szamburski A, Bringuier S, Auquier P, Capdevila X. From pain level to pain experience: redefining acute pain assessment to enhance understanding of chronic postsurgical pain. Br J Anaesth. 2024 Nov;133(5):1021-1027. doi: 10.1016/j.bja.2024.08.003. Epub 2024 Sep 26.

  PMID: 39332996 RESULT

• Doleman B, Mathiesen O, Sutton AJ, Cooper NJ, Lund JN, Williams JP. Non-opioid analgesics for the prevention of chronic postsurgical pain: a systematic review and network meta-analysis. Br J Anaesth. 2023 Jun;130(6):719-728. doi: 10.1016/j.bja.2023.02.041. Epub 2023 Apr 12.

  PMID: 37059625 RESULT

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Wei dong Mi, MD, PhD

  Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital

Study Record Dates

• First Submitted: July 26, 2026
• First Posted: August 4, 2026
• Study Start: April 1, 2020
• Primary Completion: April 30, 2024
• Study Completion: April 30, 2024
• Last Updated: August 4, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)