Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy: Analysis of Risk Factors and Association With Genetic Polymorphisms
1 other identifier
observational
3,979
1 country
26
Brief Summary
The treatment of postoperative pain continues to be inadequate in the investigators practice setting. Inadequate pain treatment not only contributes to postoperative complications in the short term but can also be a factor that favors the development of chronic postoperative pain and diminishes long-term quality of life. Risk factors that can lead to a transition to chronic pain need to be analyzed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2009
Longer than P75 for all trials
26 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2009
CompletedFirst Submitted
Initial submission to the registry
December 23, 2011
CompletedFirst Posted
Study publicly available on registry
January 16, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2014
CompletedDecember 30, 2015
December 1, 2015
3.9 years
December 23, 2011
December 29, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Evaluation of chronic postsurgical pain.
After 3 months a physical examination will take place and after 12 months a follow-up will be reported by phone.
After 3 and 12 months of surgery.
Secondary Outcomes (1)
Predictive factors of chronic postsurgical pain.
After 3 and 12 months of surgery.
Study Arms (3)
Patients who had inguinal herniorraphy.
Patients who had hysterectomy.
Patients who had thoracotomy.
Interventions
Inguinal herniorraphy (non laparoscopic).
Eligibility Criteria
All spanish patients who undergo scheduled surgery of one of the following types: inguinal herniorrhaphy, hysterectomy, toracothomy.
You may qualify if:
- Patients with given inform consent, aged mor than 18 years, who undergo scheduled surgery of one of the following types: inguinal hernia (men), hysterectomy, thoracotomy (men).
You may not qualify if:
- Patients aged less than 18 years,
- Patients requiring reoperation because of surgical complications.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Fundacion IMIMlead
Study Sites (26)
Hospital Municipal de Badalona
Badalona, Barcelona, 08911, Spain
Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
Hospital del Mar
Barcelona, Barcelona, 08003, Spain
Hospital de l'Esperança
Barcelona, Barcelona, 08024, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, 08025, Spain
Hospital Sagrat Cor
Barcelona, Barcelona, 08029, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona, 08035, Spain
Hospital Clínic i Provincial de Barcelona
Barcelona, Barcelona, 08036, Spain
Hospital del Sant Boi
Barcelona, Barcelona, 08830, Spain
Hospital de San Bernabé
Berga, Barcelona, 08600, Spain
Hospital de Granollers
Granollers, Barcelona, 08400, Spain
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital General de Manresa
Manresa, Barcelona, 08240, Spain
Hospital de Mataro
Mataró, Barcelona, 08304, Spain
Hospital Parc Tauli
Sabadell, Barcelona, 08208, Spain
Hospital Mutua de Terrassa
Terrassa, Barcelona, 08221, Spain
Hospital Universitari Mutua de Terrassa
Terrassa, Barcelona, 08227, Spain
Hospital de Viladecans
Viladecans, Barcelona, 08840, Spain
Hospital Universitari Doctor Josep Trueta de Girona
Girona, Girona, 17007, Spain
Hospital de Santa Caterina
Salt, Girona, 17190, Spain
Hospital Santa Maria
Lleida, Lleida, 25198, Spain
Hospital Sant Joan de Reus
Reus, Tarragona, 43201, Spain
Hospital Clínico de Valencia
Valencia, Valencia, 46010, Spain
Hospital General Universitario de Valencia
Valencia, Valencia, 46014, Spain
Hospital Universitari de la Fe
Valencia, Valencia, 46026, Spain
Hospital Lluís Alcanyís de Xàtiva
Xàtiva, València, 46800, Spain
Related Publications (2)
Bande D, Molto L, Pereira JA, Montes A. Chronic pain after groin hernia repair: pain characteristics and impact on quality of life. BMC Surg. 2020 Jul 6;20(1):147. doi: 10.1186/s12893-020-00805-9.
PMID: 32631293DERIVEDMontes A, Roca G, Sabate S, Lao JI, Navarro A, Cantillo J, Canet J; GENDOLCAT Study Group. Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study. Anesthesiology. 2015 May;122(5):1123-41. doi: 10.1097/ALN.0000000000000611.
PMID: 25985024DERIVED
Biospecimen
Sample collection Five milliliters of venous blood will be extracted from each patient with chronic pain; control samples will come from a DNA bank. All patients must have given their written consent to testing and storage. \- Plasma DNA will be extracted with a BioRobot EZ1 Workstation (Qiagen).
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
December 23, 2011
First Posted
January 16, 2012
Study Start
January 1, 2009
Primary Completion
December 1, 2012
Study Completion
July 1, 2014
Last Updated
December 30, 2015
Record last verified: 2015-12