Association Between Pain Catastrophizing and PONV in Laparoscopic Cholecystectomy Patients

NCT07712211 | Recruiting

• 1 other identifier: 10496660-2026/25027
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to explore whether patients' tendency to exaggerate or focus on pain (pain catastrophizing) is related to experiencing nausea and vomiting after surgery. The study will include patients undergoing laparoscopic cholecystectomy. Before surgery, patients will answer questions measuring pain catastrophizing and rate their pain during intravenous cannulation. Nausea and vomiting will be assessed at various times during the first 24 hours after surgery. The results may help better understand how psychological factors affect postoperative symptoms.

Conditions

Vomiting, Postoperative; Pain; Nausea and Vomiting, Postoperative; Pain Catastrophizing

Keywords

The Pain Catastrophizing Scale; Postoperative Nausea and Vomiting; Laparoscopic Cholecystectomy

Outcome Measures

Primary Outcomes (1)

• Incidence of postoperative nausea and vomiting (PONV)

  The primary outcome is the incidence of postoperative nausea and vomiting (PONV) according to preoperative Pain Catastrophizing Scale (PCS) scores. Patients will be evaluated for PONV at 0, 3, 6, 12, and 24 hours postoperatively. The relationship between PCS scores and the frequency of PONV will be analyzed.

  Within 24 hours postoperatively

Secondary Outcomes (1)

• Association between IV cannulation pain and pain catastrophizing

  Preoperative period

Study Arms (1)

Adult patients undergoing elective laparoscopic cholecystectomy

Aged 18 to 65 years, American Society of Anesthesiologists (ASA) physical status of I, II, III; Patients scheduled for emergency surgery , those with significant systemic diseases (ASA \> III), pregnancy, chronic opioid use, psychiatric disorders, neurological diseases, chronic renal or pulmonary disease, or those who do not provide informed consent will be exclude

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of patients undergoing elective laparoscopic cholecystectomy at Trabzon University Faculty of Medicine, Kanuni Training and Research Hospital

You may qualify if:

• Adult patients aged 18-65 years
• American Society of Anesthesiologists (ASA) physical status I-II-III
• Scheduled for elective laparoscopic cholecystectomy
• Able to provide informed consent

You may not qualify if:

• Age \<18 or \>65 years
• Emergency surgery
• ASA physical status \> III
• Pregnancy
• Chronic opioid use
• Known drug allergy
• Psychiatric disorders
• Neurological diseases (central or peripheral neuropathy)
• History of cerebrovascular disease (stroke)
• Chronic renal disease
• Chronic pulmonary disease
• Patients who refuse to participate

Sponsors & Collaborators

• Trabzon Kanuni Education and Research Hospital: lead

Study Sites (1)

Trabzon Kanuni Education and Research Hospital

Trabzon, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg. 1999 Sep;89(3):652-8. doi: 10.1097/00000539-199909000-00022.

  PMID: 10475299 BACKGROUND

• Uğurlu M, Karakaş Uğurlu G, Erten Ş, Çayköylü A. Validity of Turkish form of Pain Catastrophizing Scale and modeling of the relationship between pain-related disability with pain intensity, cognitive, and emotional factors. Psychiatry and Clinical Psychopharmacology. 2017;27(2):189-196. doi:10.1080/24750573.2017.1322672

  BACKGROUND

• Borna S, Ho OA, Gomez-Cabello CA, Haider SA, Genovese A, Prabha S, Haider CR, Felton CL, McLeod CJ, Bruce CJ, Carter RE, Forte AJ. Impact of Demographics and Psychological Factors on Three-Day Postoperative Pain Perception Following Hand Surgery. J Clin Med. 2024 Dec 25;14(1):37. doi: 10.3390/jcm14010037.

  PMID: 39797119 BACKGROUND

MeSH Terms

Conditions

Postoperative Nausea and Vomiting; Pain

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting; Neurologic Manifestations

Central Study Contacts

sedanur sula

CONTACT

+905424096196; sulasedanur@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2026
• First Posted: July 17, 2026
• Study Start: January 15, 2026
• Primary Completion: July 15, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: July 17, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)