Effect of Erector Spinae Plane Block on Postoperative Nausea and Vomiting

NCT06710457 | Completed

• 1 other identifier: ESP PONV
• Study Type: interventional
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the hypothesis that preoperative erector spinae plane (ESP) block will reduce the incidence of postoperative nausea and vomiting (PONV) in patients undergoing elective lumbar disc herniation (LDH) surgery. PONV was defined as the presence of nausea and vomiting within 24 hours postoperatively.

Conditions

Anesthesia; Pain, Postoperative; Nausea and Vomiting, Postoperative

Keywords

Erector spinae plane block; Postoperative nausea vomiting; Apfel score

Outcome Measures

Primary Outcomes (1)

• PONV

  The primary outcome of the study was the incidence of postoperative nausea and/or vomiting

  24 hours

Secondary Outcomes (5)

• Severity of nausea

  24 hours

• 11 - point numerical rating scale (NRS)

  24 hours

• Rescue antiemetic requirement

  24 hours

• Rescue analgesic requirement

  24 hours

• intraoperative opioid requirement

  intraoperative time

Study Arms (2)

Erector spinae plane (ESP) block

ACTIVE COMPARATOR

Patients will receive an erector spinae plane (ESP) block in addition to standard medical treatment to prevent PONV and postoperative pain.

Other: ESP

No Erector spinae plane (ESP) block

ACTIVE COMPARATOR

Patients will receive standard medical treatment to prevent PONV and postoperative pain.

Other: No ESP

Interventions

ESP OTHER

Patients will receive an erector spinae plane (ESP) block in addition to standard medical treatment to prevent PONV and postoperative pain.

Erector spinae plane (ESP) block

No ESP OTHER

Patients will receive standard medical treatment to prevent PONV and postoperative pain.

No Erector spinae plane (ESP) block

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 and above
• ASA physical status I to II
• One lumbar disc herniation surgery under general anesthesia

You may not qualify if:

• body mass index \>35 kg/m²)
• history of drug use
• nausea and vomiting before surgery
• psychiatric disorders
• use of antipsychotic or antiemetic drugs
• severe heart disease
• central nervous system diseases
• vertebrobasilar artery insufficiency
• cytostatic therapy
• vestibular diseases
• renal and/or hepatic dysfunction
• pregnant patients
• presence of bleeding diathesis
• patients in a condition where cooperation cannot be established in the post-operative period (mental retardation etc.)
• patient's refusal to accept the block procedure

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Ankara, Çankaya, 06800, Turkey (Türkiye)

Location

Related Publications (1)

• Erdem G, Kavak Akelma F, Nalbant B, Gokbulut Ozaslan N. Effect of erector spinae plane block on postoperative nausea and vomiting in lumbar disc herniation surgery. Reg Anesth Pain Med. 2025 Jun 30:rapm-2025-106756. doi: 10.1136/rapm-2025-106756. Online ahead of print.

  PMID: 40588358 DERIVED

MeSH Terms

Conditions

Pain, Postoperative; Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Vomiting

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology and Reanimation specialist doctor

Study Record Dates

• First Submitted: November 26, 2024
• First Posted: November 29, 2024
• Study Start: December 11, 2024
• Primary Completion: March 15, 2025
• Study Completion: April 14, 2025
• Last Updated: April 15, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)