Sensory Distribution and Postoperative Analgesia of Ultrasound-Guided Interfascial Plane Blocks in Living Liver Donors

NCT07252063 | Recruiting

• 1 other identifier: Liver mapping
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Living liver donor hepatectomy at our institution routinely includes ultrasound-guided interfascial plane blocks as part of postoperative analgesia. Although these blocks have become increasingly used in donor hepatectomy, their cutaneous sensory distributions and block-related dermatomal coverage have not been systematically evaluated, with only anecdotal reports available in the literature. This prospective observational study aims to assess both the sensory blockade patterns and the early postoperative analgesic performance of interfascial plane blocks administered to living liver donors. Following surgery, all consenting donors receive the institution's standard block protocol. Cutaneous sensory mapping is performed in the post-anesthesia care unit (PACU) at the second postoperative hour. Pain intensity and analgesic requirements within the first 24 hours are also recorded. The study is designed to provide objective data on the dermatomal coverage and postoperative analgesic effects of contemporary ultrasound-guided interfascial plane blocks used in living liver donor surgery.

Conditions

Pain

Outcome Measures

Primary Outcomes (1)

• Cutaneous sensory block area mapping for different regional anesthesia techniques in liver donor surgery

  The cutaneous sensory block area produced by the regional anesthesia technique will be evaluated at the 120th minute post-block using a standardized pinprick test. Sensory borders will be identified radially and marked on the skin with a UV-visible marker. Each mapped region will be photographed with a calibrated reference scale placed on the skin. These images will be processed using a predefined digital template to calculate the total blocked surface area in square centimeters. The resulting measurements will be used to characterize the sensory distribution of the interfascial plane blocks in living liver donors.

  At 120 minutes after block administration in the post-anesthesia care unit (PACU).

Interventions

interfascial plane block OTHER

Ultrasound-guided interfascial plane blocks are administered at the end of surgery. Block selection and needle entry points are determined according to the surgical incision line and the location of abdominal drains. All blocks are performed under real-time ultrasound guidance using the institution's standardized protocol.

patient controlled analgesia device OTHER

Intravenous patient-controlled analgesia is initiated in the postoperative period according to the institution's standard protocol. PCA settings, opioid type, basal infusion (if applicable), and bolus doses follow routine clinical practice and are recorded for analysis. PCA use during the first 24 hours is monitored to assess postoperative analgesic requirements.

cutaneus sensory mapping OTHER

Cutaneous sensory mapping is performed in the post-anesthesia care unit (PACU) at the second postoperative hour. Sensory blockade is assessed using a standardized pinprick test applied radially from medial to lateral directions. The borders of the blocked and unblocked regions are marked on the skin using a UV-visible dermatographic pen. Mapping is conducted over the mid-abdominal and lateral abdominal regions, and the total cutaneous coverage areas are subsequently calculated for analysis.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult living liver donors undergoing elective donor hepatectomy at a tertiary care center. All participants receive ultrasound-guided interfascial plane blocks as part of the institution's routine postoperative analgesia protocol. Eligible donors are aged 18 to 65 years, classified as ASA physical status I-II, and able to cooperate with postoperative cutaneous sensory mapping procedures. Individuals with contraindications to regional anesthesia, conditions preventing accurate sensory assessment, or those who decline participation are excluded.

You may qualify if:

• Adult living liver donors undergoing elective donor hepatectomy
• Age 18 to 65 years
• ASA physical status I-II
• Patients who have received ultrasound-guided interfascial plane blocks as part of their postoperative analgesia
• Ability to cooperate with postoperative sensory mapping procedures
• Patients who agree to participate and provide written informed consent

You may not qualify if:

• Patients who refuse to participate or do not provide written informed consent
• Patients who have not received any ultrasound-guided interfascial plane block
• ASA physical status \> II
• Presence of surgical incisions or wound complications preventing reliable sensory mapping
• Prior major abdominal surgery that may alter cutaneous innervation patterns
• Cognitive impairment limiting the ability to cooperate with sensory testing
• Known psychiatric disorders (e.g., major depression, mania, schizophrenia) that may interfere with postoperative assessment
• Local infection, skin disease, or dermatologic condition preventing accurate cutaneous mapping
• Allergy or contraindication to local anesthetics used in the block

Sponsors & Collaborators

• Bahçeşehir University: lead

Study Sites (1)

Bahcesehir Unişversity Medicalpark Goztepe hospital

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Selma Kahyaoglu

CONTACT

+905053705332; selmabsygt@hotmail.com

Serkan Tulgar

CONTACT

+905055423985; serkantulgar.md@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Anesthesiology

Study Record Dates

• First Submitted: November 19, 2025
• First Posted: November 26, 2025
• Study Start: November 1, 2025
• Primary Completion: December 31, 2025
• Study Completion: January 1, 2026
• Last Updated: November 26, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)