Asprosin and Total Antioxidant/Oxidant Status in Diabetes and Periodontal Disease

NCT07691060 | Completed

• 2 other identifiers: 2025-2182024/077
• Study Type: observational
• Target: 67
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about how different periodontal health status affects the levels of asprosin (a hormone) and total oxidant/antioxidant status in the gingival crevicular fluid and blood serum of individuals with Type 2 diabetes. The main questions it aims to answer are: Do individuals with Type 2 diabetes and periodontal disease have different levels of asprosin and oxidative stress markers compared to diabetic individuals with healthy gingiva ? How do local changes in the gingiva relate to systemic (body-wide) biomarkers in diabetic patients? Participants with Type 2 diabetes will undergo a routine clinical periodontal examination to evaluate their gingival health. During their regular clinic visit, samples of fluid from around their gingiva (gingival crevicular fluid) and routine blood samples (serum) will be collected to measure and compare these biochemical markers

Conditions

Periodontal Diseases; Gingival Diseases; Type 2 Diabetes

Keywords

asprosin; periodontitis; gingivitis; total oxidant status; total antioxidant status; oxidative stress

Outcome Measures

Primary Outcomes (1)

• Comparison of serum and gingival crevicular fluid asprosin levels among individuals with type 2 diabetes mellitus presenting different periodontal conditions.

  At a single study visit during enrollment

Secondary Outcomes (1)

• Comparison of serum and gingival crevicular fluid total oxidant status and total antioxidant status levels among individuals with type 2 diabetes mellitus presenting different periodontal conditions.

  At a single study visit during enrollment

Study Arms (3)

Periodontal health

Systemic and periodontal health participants

Gingivitis

Type 2 Diabetes and gingivitis

Periodontitis

Type 2 Diabetes and periodontitis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of adults aged 18-65 years. The gingivitis and periodontitis groups included patients diagnosed with type 2 diabetes mellitus (T2DM), whereas the healthy control group consisted of systemically healthy individuals. Participants were required to be non-smokers, have more than 20 natural teeth, and have no systemic conditions or medication use that could affect the immune response of the periodontal tissues.

You may qualify if:

• Patients with type 2 diabetes mellitus (T2DM) in the gingivitis and periodontitis groups
• Systemically healthy individuals without any systemic disease in the healthy control group
• Age between 18 and 65 years
• Non-smokers
• Individuals with no diseases or medication use that could alter the immune response of the periodontal tissues
• Participants with more than 20 natural teeth

You may not qualify if:

• Age younger than 18 years or older than 65 years
• Smokers
• Individuals with any disease or medication use that could alter the immune response of the periodontal tissues
• Pregnant women
• Individuals who had received periodontal treatment within the previous 6 months
• Patients with type 1 diabetes mellitus (T1DM)
• Individuals who had used antibacterial medications within the previous 6 months

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

University of Health Sciences Türkiye, Gülhane Faculty of Dentistry

Ankara, Ankara, 06100, Turkey (Türkiye)

Location

Related Links

• Related Info

MeSH Terms

Conditions

Periodontal Diseases; Gingival Diseases; Diabetes Mellitus, Type 2; Arachnodactyly; Periodontitis; Gingivitis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Limb Deformities, Congenital; Musculoskeletal Abnormalities; Musculoskeletal Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: June 12, 2026
• First Posted: July 8, 2026
• Study Start: July 1, 2025
• Primary Completion: December 17, 2025
• Study Completion: December 30, 2025
• Last Updated: July 8, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)