Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients

NCT07384221 | Recruiting

• 1 other identifier: 2025-161
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.

Conditions

Pemphigus Vulgaris (PV); Periodontal Diseases

Keywords

Pemphigus Vulgaris; Periodontitis; Desmoglein; ODSS (Oral Disease Severity Score)

Outcome Measures

Primary Outcomes (1)

• Oral Disease Severity Score (ODSS)

  A clinical scoring system used to assess the severity of oral mucosal involvement in patients with Pemphigus Vulgaris. It evaluates the site and extent of lesions in the oral cavity.

  Baseline

Secondary Outcomes (5)

• Serum Desmoglein 1 and 3 Levels

  Baseline

• Clinical Attachment Level (CAL)

  Baseline

• Probing Pocket Depth (PPD)

  Baseline

• Plaque Index (PI)

  Baseline

• Gingival Index (GI)

  Baseline

Study Arms (1)

Pemphigus Vulgaris Group

A comprehensive oral examination including ODSS scoring and periodontal measurements (PPD, CAL, PI, GI). Additionally, serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for biochemical correlation.

Other: Clinical Periodontal and Oral Evaluation

Interventions

Clinical Periodontal and Oral Evaluation OTHER

"Participants will undergo a comprehensive oral examination. The severity of oral mucosal involvement will be recorded using the Oral Disease Severity Score (ODSS). Clinical periodontal parameters, including Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL), will be measured at six sites per tooth using a periodontal probe. Additionally, current serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for clinical correlation."

Pemphigus Vulgaris Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients diagnosed with Pemphigus Vulgaris who are receiving treatment or follow-up at the dermatology clinic.

You may qualify if:

• Patients aged 18 years and older.
• Clinically and histopathologically confirmed diagnosis of Pemphigus Vulgaris.
• Presence of at least 10 natural teeth.
• Willingness to participate and signed informed consent.

You may not qualify if:

• Pregnancy or lactation.
• Use of systemic antibiotics or anti-inflammatory drugs within the last 3 months.
• Periodontal treatment received within the last 6 months.

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology

Ankara, 06010, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Pemphigus; Periodontal Diseases; Periodontitis

Interventions

Diagnosis, Oral

Condition Hierarchy (Ancestors)

Skin Diseases, Vesiculobullous; Skin Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dentistry

Study Officials

• Nuriye Işıl Saygun, Professor

  University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Bilkan KARA, Dr.

CONTACT

+905383781679; bilkankara@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Department of Periodontology

Study Record Dates

• First Submitted: January 26, 2026
• First Posted: February 3, 2026
• Study Start: November 1, 2025
• Primary Completion: January 30, 2026
• Study Completion: February 21, 2026
• Last Updated: February 3, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)