NCT07682597

Brief Summary

This clinical trial studies whether a Quality Implementation of Lung Cancer Screening (QUILS™) System state-based initiative (SBI) intervention works to improve the statewide capacity for implementing and sustaining lung cancer screening in Mississippi (MS) and Nevada (NV). The QUILS™ Group is focused on fair and high-quality implementation of lung cancer screening among eligible individuals to reduce lung cancer-related death in underserved communities. Previous research had success with implementing interventions in Kentucky which has lead to significant increases in lung cancer screening rates and a rapid decline in late-stage lung cancer diagnoses within the state. The goal is to offer the opportunity to replicate this work in states which are eager to address suboptimal screening rates, high lung cancer-related death, and significant health equity concerns. The QUILS™ SBI intervention involves translating the success of the initial work in Kentucky to impact lung cancer screening implementation and lung cancer outcomes in MS and NV through close collaboration with state-based partners. The QUILS™ SBI intervention may be an effective way to improve the statewide capacity for implementing and sustaining lung cancer screening in MS and NV.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
36mo left

Started Mar 2026

Longer than P75 for not_applicable

Geographic Reach
1 country

13 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress13%
Mar 2026Jul 2029

Study Start

First participant enrolled

March 1, 2026

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

June 26, 2026

Completed
10 days until next milestone

First Posted

Study publicly available on registry

July 6, 2026

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2028

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2029

Last Updated

July 6, 2026

Status Verified

June 1, 2026

Enrollment Period

2.3 years

First QC Date

June 26, 2026

Last Update Submit

June 26, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Statewide Capacity Assessment Scores for Lung Cancer Screening Implementation and Sustainability Capacity

    Statewide capacity will be assessed using the State Team Assessment (STA) and Coalition Assessment (CA) instruments. Higher scores indicate greater capacity to implement an sustain lung cancer screening activities.

    Up to 3 Years

Study Arms (1)

Health Services Research (SBI Intervention)

EXPERIMENTAL

Participants implement the QUILS™ SBI intervention over 4 years consisting of the following steps: 1) Hire and establish connections with both groups, work with the MSLCRT and NLCC during year 1; 2) Participate in annual meetings hosted by MSCLRT and NLCC during years 1-4; 3) Attend State Team Assessment Feedback Sessions during years 2-4; 4) Attend Coalition Assessment Feedback Sessions during years 2-4; 5) Prioritize objectives, identify areas to support, implementation of state-based initiative, and receive coaching/support during years 2 and 3; 6) Receive coaching and technical assistance to implement priority areas during years 1-4; 7) Participate in sustainability planning during year 4.

Behavioral: QUILS SBI Intervention

Interventions

Participants implement the QUILS™ SBI intervention over 4 years consisting of the following steps: 1) Hire and establish connections with both groups, work with the MSLCRT and NLCC during year 1; 2) Participate in annual meetings hosted by MSCLRT and NLCC during years 1-4; 3) Attend State Team Assessment Feedback Sessions during years 2-4; 4) Attend Coalition Assessment Feedback Sessions during years 2-4; 5) Prioritize objectives, identify areas to support, implementation of state-based initiative, and receive coaching/support during years 2 and 3; 6) Receive coaching and technical assistance to implement priority areas during years 1-4; 7) Participate in sustainability planning during year 4.

Health Services Research (SBI Intervention)

Eligibility Criteria

Age18 Years - 100 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Member of a state-based lung cancer screening implementation team in Mississippi or Nevada.
  • Leadership member of the Mississippi state team or Nevada state team
  • Active member of the Mississippi Lung Cancer Roundtable (MSLCRT) or Nevada Lung Cancer Coalition (NLCC)
  • Willing to participate in study-related assessments an implementation activities

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (13)

Delta Health System

Greenville, Mississippi, 38703, United States

RECRUITING

Greenwood Leflore Hospital

Greenwood, Mississippi, 38930, United States

RECRUITING

Memorial Hospital Gulfport

Gulfport, Mississippi, 39501, United States

RECRUITING

Hattiesburg Clinic

Hattiesburg, Mississippi, 39401, United States

RECRUITING

University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States

RECRUITING

Baptist Memorial Hospital

New Albany, Mississippi, 38652, United States

RECRUITING

North Mississippi Health Services

Tupelo, Mississippi, 38801, United States

RECRUITING

Mt. Grant General Hospital

Hawthorne, Nevada, 89415, United States

RECRUITING

Desert View Hospital

Pahrump, Nevada, 89048, United States

RECRUITING

Renown Regional Medical Center

Reno, Nevada, 89502, United States

RECRUITING

Sierra Medical Center

Reno, Nevada, 89511, United States

RECRUITING

Sunrise Health

Winchester, Nevada, 89109, United States

RECRUITING

Humboldt General Hospital

Winnemucca, Nevada, 89445, United States

RECRUITING

Central Study Contacts

Joseph Alexander, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 26, 2026

First Posted

July 6, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

July 1, 2028

Study Completion (Estimated)

July 1, 2029

Last Updated

July 6, 2026

Record last verified: 2026-06

Locations