Impact of Periodontitis Grading on Peri-Implant Clinical and Bone Health: A 60-Month Prospective Study

NCT07671456 | Completed DMC

• 1 other identifier: 0015.0.167.0000-10
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study evaluated the effect of periodontitis grading on peri-implant clinical and radiographic outcomes over a 60-month follow-up. Fifty-five partially edentulous patients were classified into three groups according to periodontal status: generalized aggressive periodontitis (Grade C), generalized chronic periodontitis (Grade B), and no history of periodontitis. A total of 92 implants (tissue- or bone-level) were placed and restored with single crowns, followed by biannual supportive periodontal therapy. Peri-implant clinical parameters (probing depth, clinical attachment level, plaque index, and bleeding on probing), marginal bone level changes, peri-implantitis incidence, and implant survival were assessed up to 60 months after prosthetic loading. The objective was to determine whether periodontal history and grading influence long-term peri-implant outcomes under maintenance therapy.

Conditions

Dental Implants; Aggressive Periodontitis; Chronic Periodontitis; Staging; Peri-implantitis

Outcome Measures

Primary Outcomes (1)

• Marginal bone level changes around dental implants evaluated radiographically.

  Primary Outcome

  Over a 60-month follow-up period.

Secondary Outcomes (3)

• Peri-implant probing depth (PPD) at follow-up visits

  Over a 60-month follow-up period

• Bleeding on probing (BoP) around implants

  60 months follow-up

• Implant survival rate

  60 months follow-up

Study Arms (3)

GAP Group

Patients with a history of generalized aggressive periodontitis, rehabilitated with dental implants.

GCP Group

Patients with a history of generalized chronic periodontitis, rehabilitated with dental implants.

PPH Group

Periodontally healthy patients or Patients with no history of periodontitis (no site with probing depth \> 3mm and bleeding on probing \< 20%)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with or without a history of periodontitis were included in the study

You may qualify if:

• Age ≥ 18 years.
• Previous diagnosis of aggressive periodontitis, chronic periodontitis, or no history of periodontitis.
• Completion of periodontal treatment at least 1 year before study enrollment.
• Enrollment in supportive periodontal therapy.
• Plaque Index \< 20% at study onset.
• Bleeding on Probing \< 20% at study onset.
• Presence of at least one single edentulous space with adjacent teeth.
• Sufficient bone and soft tissue volume for implant placement without the need for reconstructive procedures.

You may not qualify if:

• Systemic conditions that contraindicate implant surgery.
• Use of systemic antimicrobial therapy within 6 months before implant placement.
• Untreated or uncontrolled aggressive periodontitis.
• Untreated or uncontrolled chronic periodontitis.
• Pregnancy or breastfeeding.
• Need for bone grafting or soft tissue grafting procedures.
• Current smokers or former smokers.

Sponsors & Collaborators

• University of Campinas, Brazil: lead

Related Publications (5)

• Pimentel SP, Shiota R, Cirano FR, Casarin RCV, Pecorari VGA, Casati MZ, Haas AN, Ribeiro FV. Occurrence of peri-implant diseases and risk indicators at the patient and implant levels: A multilevel cross-sectional study. J Periodontol. 2018 Sep;89(9):1091-1100. doi: 10.1002/JPER.17-0599. Epub 2018 Aug 8.

  PMID: 29761866 BACKGROUND

• Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, Chen S, Cochran D, Derks J, Figuero E, Hammerle CHF, Heitz-Mayfield LJA, Huynh-Ba G, Iacono V, Koo KT, Lambert F, McCauley L, Quirynen M, Renvert S, Salvi GE, Schwarz F, Tarnow D, Tomasi C, Wang HL, Zitzmann N. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun;89 Suppl 1:S313-S318. doi: 10.1002/JPER.17-0739.

  PMID: 29926955 BACKGROUND

• Salvi GE, Stahli A, Imber JC, Sculean A, Roccuzzo A. Physiopathology of peri-implant diseases. Clin Implant Dent Relat Res. 2023 Aug;25(4):629-639. doi: 10.1111/cid.13167. Epub 2022 Dec 14.

  PMID: 36515007 BACKGROUND

• Lang NP. Implant Dentistry: The Past, the Present, the Future. J Periodontal Res. 2025 Feb;60(2):97-100. doi: 10.1111/jre.13388. Epub 2025 Feb 21. No abstract available.

  PMID: 39980414 BACKGROUND

• Karoussis IK, Salvi GE, Heitz-Mayfield LJ, Bragger U, Hammerle CH, Lang NP. Long-term implant prognosis in patients with and without a history of chronic periodontitis: a 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res. 2003 Jun;14(3):329-39. doi: 10.1034/j.1600-0501.000.00934.x.

  PMID: 12755783 BACKGROUND

MeSH Terms

Conditions

Aggressive Periodontitis; Chronic Periodontitis; Peri-Implantitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 60 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Periodontology

Study Record Dates

• First Submitted: June 22, 2026
• First Posted: June 26, 2026
• Study Start: January 1, 2011
• Primary Completion: June 1, 2017
• Study Completion: January 1, 2019
• Last Updated: June 26, 2026

Record last verified: 2026-06