Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients
IVDAP
1 other identifier
observational
61
0 countries
N/A
Brief Summary
The study was to intended to visualize the nuclear localization of vitamin D receptor in oral tissues of aggressive periodontitis patients to better understand the potential for receptor in disease activity or progression.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Nov 2010
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedFirst Submitted
Initial submission to the registry
October 31, 2014
CompletedFirst Posted
Study publicly available on registry
November 4, 2014
CompletedNovember 4, 2014
October 1, 2014
9 months
October 31, 2014
October 31, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
Less nuclear receptors in aggressive periodontitis
Immunohistochemical staining has been done for test group and control group tissue samples where less nuclear vitamin D receptors are found in aggressive periodontitis patients.
24hrs
Study Arms (2)
Case group
Case group include patients with generalized AgP were the tissue samples taken to analyse the number of vitamin D receptor present.
Control group
Ethnically matched, systemically and periodontally healthy individuals were included in control group were also gingival tissue taken for analysis of number of receptors present in nucleus and cytoplasm
Interventions
50-100mg gingival tissue samples were collected from both test and control group for immunohistochemical staining to assess the number of vitamin D receptors in nucleus as well cytoplasm and also for RNA isolation to check the presence of VDR gene.
Eligibility Criteria
The study population was divided in to two groups i.e test and control group
You may qualify if:
- Generalized Aggressive periodontitis patients were onset of periodontal disease at \<35yrs of age and atleast eight teeth with probing depth \>6mm and radiographic evidence of alveolar bone loss, three of which were not first molar or incisor under test group.
- Control group includes systemically and periodontally healthy individuals who is of same age as that of test group.
You may not qualify if:
- Subjects taking drugs for vitamin D or calcium
- Subjects received periodontal therapy within previous year
- Pregnant subjects
- Smokers
- Patients with systemic diseases -
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Rajashree Dasari, MDS
Panineeya Mahavidyalaya
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients
Study Record Dates
First Submitted
October 31, 2014
First Posted
November 4, 2014
Study Start
November 1, 2010
Primary Completion
August 1, 2011
Study Completion
December 1, 2011
Last Updated
November 4, 2014
Record last verified: 2014-10