Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis

NCT01246596 | Completed

• 1 other identifier: 10-AOI-01
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.

Conditions

Chronic Periodontitis; Aggressive Periodontitis; Presence / Absence of EBV

Outcome Measures

Primary Outcomes (1)

• Percentage of gingival epithelial cells infected by EBV (by immunofluorescence and In situ Hybridization)

  at time=0

Secondary Outcomes (2)

• Epithelial tissue infected by EBV (by immunofluorescence and in situ hybridization)

  at time = 0

• Presence / absence of latency and / or lytic proteins (by immunofluorescence and in situ hybridization)

  at time = 0

Study Arms (3)

chronic periodontitis

ACTIVE COMPARATOR

Procedure: dental root planing

aggressive periodontitis

ACTIVE COMPARATOR

Procedure: dental root planing

healthy patient (orthodontics extraction)

ACTIVE COMPARATOR

Procedure: dental root planing

Interventions

dental root planing PROCEDURE

The objective of root planing, otherwise known as conventional periodontal therapy, non-surgical periodontal therapy, or dental prophylaxis is to remove or eliminate the etiologic agents which cause inflammation: dental plaque, its products and calculus,\[1\] thus helping to establish a periodontium that is free of disease.\[2\]

chronic periodontitis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients affected by chronic periodontitis
• patients affected by aggressive periodontitis
• healthy patients (orthodontics extraction)
• Subject who have read and understood the information note relative under investigation and who have signed the informed consent
• major patient

You may not qualify if:

• Patient with no contre-indication to periodontal treatment
• Patient with serious blood disease
• Patient who exhibits systemic condition incompatible with realization of the study
• Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
• Patient who presents a buccal carcinoma treated with radiotherapy
• Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
• Patient who presents a linguistic or psychic incapacity to understand information

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

Dr Severine VINCENT

Nice, 0600, France

Location

MeSH Terms

Conditions

Chronic Periodontitis; Aggressive Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Severine VINCENT, PH

  CHU de Nice Hôpital Saint Roch

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2010
• First Posted: November 23, 2010
• Study Start: January 1, 2011
• Primary Completion: May 5, 2014
• Study Completion: May 5, 2014
• Last Updated: November 13, 2023

Record last verified: 2023-11

Locations

FR (1)