Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients

NCT07671274 | Recruiting Early Phase 1 DMC

• 1 other identifier: R.25.07.9 - 2025/08/05
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

the aim of this study is to investigate the clinical outcomes of Minimally Invasive Non-Surgical Therapy(MINST) compared to Conventional non-surgical periodontal therapy (CNST)

Conditions

Periodontal Disease; Stage III Periodontitis

Keywords

periodontitis; stage III; mechanical debridement

Outcome Measures

Primary Outcomes (4)

• Plaque index (PI)

  1\. Plaque index (PI):The index assigns a score to each tooth based on the amount of plaque present. 0: No plaque is visible. 1. A thin film of plaque is present at the gingival margin (gumline) and can be detected with a probe. 2. Visible plaque along the gingival margin. 3. Heavy plaque accumulation in the gingival margin and interdental spaces.

  basline, 1 month , 3 months

• Bleeding on probing (BOP):

  ): "0" if no bleeding occurred within 10 second, and "1" if there was bleeding within 10 second.

  baseline, 1 month , 3 months

• Probing pocket Depth (PPD)

  ): will be measured from the gingival margin to the base of the periodontal pocket.

  baseline , 1 month , 3 month

• Clinical Attachment Level (CAL)

  will be measured from the cement-enamel junction to the base of the periodontal pocket.

  baseline ,1 month , 3 month

Study Arms (2)

conventional non-surgical periodontal therapy

EXPERIMENTAL

conventional mechanical debridement

Device: Mechanical debridement .

Minimally Invasive Non-Surgical Therapy

EXPERIMENTAL

the root surface of teeth will be thoroughly debrided by a minimally invasive approach using specific thin and delicate piezo-electric scaling tips (Woodpecker � Tip P3. Am Perfect sp. z o .• � Poland) and manual miniature periodontal curettes {� Dent Solutions. Cairo. Egypt) for reducing periodontal tissue trauma. Adjunctive use of magnification loupes will be performed.

Device: minimally invasive mechanical debridement

Interventions

Mechanical debridement . DEVICE

On the conventional non-surgical periodontal therapy side, a power-driven piezo•electric ultrasonic scaling device with scaling tips will be used the majority of the time to debride subgingival biofilm and calculus. and manual standard gracey curette instruments will be used to refine residuals from root surfaces.

conventional non-surgical periodontal therapy

minimally invasive mechanical debridement DEVICE

Briefly. the root surface of teeth will be thoroughly debrided by a minimally invasive approach using specific thin and delicate piezo-electric scaling tips (Woodpecker � Tip P3. Am Perfect sp. z o .• � Poland) and manual miniature periodontal curettes {� Dent Solutions. Cairo. Egypt) for reducing periodontal tissue trauma. Adjunctive use of magnification loupes will be performed.

Minimally Invasive Non-Surgical Therapy

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with stage III pericdontitis, according to the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) periodontal classification system .
• Medically free patients.
• Non-smokers
• Patients with good oral hygiene.

You may not qualify if:

• Pregnant or lactating females.
• Patients with systemic diseases that might affect periodontal health
• previous periodontal treatment within 6 months before baseline examination.
• prior antibiotic regimen use within 1 month before baseline examination

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura university Faculty of dentistry

Al Mansurah, Dakhlia, 00000, Egypt

RECRUITING

MeSH Terms

Conditions

Periodontal Diseases; Periodontitis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Central Study Contacts

fatma saad elsherbini, phd

CONTACT

+201128065677; elsherbinifatma@mans.edu.eg

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, Lecturer, Oral Medicine, Periodontology, Diagnosis, and Oral Radiology Department,

Study Record Dates

• First Submitted: June 16, 2026
• First Posted: June 26, 2026
• Study Start: August 5, 2025
• Primary Completion (Estimated): August 5, 2026
• Study Completion (Estimated): August 5, 2026
• Last Updated: June 26, 2026

Record last verified: 2026-06

Locations

EG (1)