Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a Relation to Periodontal Inflammaging

NCT06677736 | Completed DMC FDA Device

• 1 other identifier: 2022\0083
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging

Conditions

Periodontal Disease

Keywords

inflamaging

Outcome Measures

Primary Outcomes (3)

• Clinical attachment loss

  Base line , follow up after 1 month , second follow up after 6 months

• Gingival index

  base line, follow up after 1 month, second follow up after 6 months

• Toll like receptor - 4

  base line, follow up after 1 month, second follow up after 6 months

Study Arms (4)

conventional scaling and debridement young age patient

EXPERIMENTAL

conventional scaling and debridement young age patient

Procedure: conventional scaling and debridement

conventional scaling and debridement old age patient

EXPERIMENTAL

conventional scaling and debridement old age patient

Procedure: conventional scaling and debridement

diode laser as adjunctive to scaling and debridement young age patient

EXPERIMENTAL

diode laser as adjunctive to scaling and debridement young age patient

Radiation: Diode laser as adjunctive to conventional scaling and debridement

diode laser as adjunctive to scaling and debridement old age patient

EXPERIMENTAL

diode laser as adjunctive to scaling and debridement old age patient

Radiation: Diode laser as adjunctive to conventional scaling and debridement

Interventions

conventional scaling and debridement PROCEDURE

conventional scaling and debridement

conventional scaling and debridement old age patient; conventional scaling and debridement young age patient

Diode laser as adjunctive to conventional scaling and debridement RADIATION

Diode laser as adjunctive to conventional scaling and debridement

diode laser as adjunctive to scaling and debridement old age patient; diode laser as adjunctive to scaling and debridement young age patient

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or Female
• Aged below 40 or above 60.
• Have at least 16 natural teeth excluding wisdom.
• Provide informed consent and willingness to cooperate with study protocol.
• Periodontitis stage II patients (23):
• CAL from 3-4 mm.
• Radiographic bone loss (15% to 33%).
• No tooth loss due to periodontitis.
• Maximum probing depth ≤ 5 mm, mostly horizontal bone loss

You may not qualify if:

• Patients with any smoking habits 2- History of antibiotics in the previous three months. 3- Pregnant or lactating female. 4- Treatment with any systemic drug. 5- History of systemic disease. 6- Patients who received periodontal treatment in the last 6 months

Sponsors & Collaborators

• Rawda Saleh Saad Alashmawy: lead

Study Sites (1)

Misr university for science and technology

Giza, Giza Governorate, 3220001, Egypt

Location

MeSH Terms

Conditions

Periodontal Diseases

Interventions

Debridement; Lasers, Semiconductor

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Surgical Procedures, Operative; Lasers; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: dentist

Study Record Dates

• First Submitted: November 5, 2024
• First Posted: November 7, 2024
• Study Start: July 12, 2023
• Primary Completion: March 12, 2024
• Study Completion: October 12, 2024
• Last Updated: November 7, 2024

Record last verified: 2024-11

Locations

EG (1)