Mean Platelet Volume (MPV) as an Early Predictor of Mortality in Intensive Care Patients With Cancer

NCT07656311 | Enrolling By Invitation

• 1 other identifier: 2026-05/106
• Study Type: observational
• Target: 425
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate whether Mean Platelet Volume (MPV) and other blood count parameters measured at admission can predict mortality in cancer patients admitted to the intensive care unit (ICU). Patients with cancer are highly vulnerable to complications and organ failure, making early risk assessment vital for improving treatment strategies. Researchers will retrospectively review the medical charts and electronic health records of adult patients who stayed in the anesthesia ICU for longer than 24 hours between 2020 and 2025. No new laboratory tests, interventions, or patient contact will occur. The collected data will be analyzed to determine the relationship between initial MPV levels and patient survival outcomes.

Conditions

Critical Illness; Cancer; Mortality

Keywords

Mean Platelet Volume; cancer; Intensive Care Unit; ICU Mortality; Biomarkers; MPV

Outcome Measures

Primary Outcomes (1)

• Intensive Care Unit (ICU) Mortality

  The percentage of oncological patients who died during their stay in the anesthesia intensive care unit. This will be calculated based on the electronic health records and patient files.

  From the date of ICU admission up to ICU discharge, assessed up to 30 days.

Secondary Outcomes (1)

• Hospital Mortality

  From the date of hospital admission up to hospital discharge, assessed up to 60 days.

Study Arms (1)

Oncological ICU Patients

Adult patients (aged 18 and older) with a confirmed cancer diagnosis who were admitted to the anesthesia intensive care unit for longer than 24 hours between the years 2020 and 2025

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult oncological patients who required critical care and were admitted to the anesthesia intensive care unit of a tertiary oncology training and research hospital between 2020 and 2025.

You may qualify if:

• Adult patients aged 18 years and older.
• Patients with a pathologically or clinically confirmed diagnosis of cancer (solid or hematological malignancies).
• Patients who were admitted to the Anesthesia Intensive Care Unit (ICU) between 2020 and 2025.
• Patients with an ICU length of stay longer than 24 hours.
• Patients with complete medical records, including baseline complete blood count (CBC) and Mean Platelet Volume (MPV) measured at the time of ICU admission.

You may not qualify if:

• Patients under the age of 18.
• Patients who stayed in the intensive care unit for less than 24 hours.
• Patients with missing or incomplete medical charts, laboratory data, or survival status records.
• Patients who were readmitted to the ICU during the same hospital stay (only the first admission will be evaluated).
• Patients who received massive blood or platelet transfusions immediately prior to the baseline laboratory measurement, which could artificially alter platelet parameters.

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Critical Illness; Neoplasms

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Eda Cennet Caferoğlu

Study Record Dates

• First Submitted: June 15, 2026
• First Posted: June 18, 2026
• Study Start: June 15, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: June 18, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)