Continuous Renal Replacement Therapy Circuit Lifespan in Intensive Care Patients

NCT07842562 | Completed

• 1 other identifier: 2026-09/218
• Study Type: observational
• Target: 162
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements change over time. The main questions it aims to answer are: Are higher maximum and mean transmembrane pressure (TMP) values associated with longer CRRT circuit lifespan? Do time-normalized pressure trajectories and cumulative TMP burden differ between circuits with different lifespans? Do access pressure patterns influence the relationship between pressure measurements and circuit lifespan? Researchers will analyze archived CRRT device log files, including access pressure, filter pressure, effluent pressure, return pressure, and TMP measurements. No additional procedures, interventions, or study visits will be required. No directly identifiable patient information will be included in the analytical dataset.

Conditions

Critical Illness; Acute Kidney Injury

Keywords

Continuous Renal Replacement Therapy; Continuous Kidney Replacement Therapy; CRRT Circuit Lifespan; Transmembrane Pressure; Circuit Pressure Dynamics

Outcome Measures

Primary Outcomes (1)

• Maximum Transmembrane Pressure Across CRRT Circuit Lifespan Categories

  To compare maximum transmembrane pressure values among CRRT sessions grouped by circuit lifespan: less than 12 hours, 12 to less than 24 hours, 24 to less than 48 hours, and 48 hours or longer.

  From the first to the last valid pressure recording of each CRRT session

Secondary Outcomes (1)

• Initial 6-hour TMP slope

  During the first 6 hours of each CRRT session

Study Arms (4)

CRRT Circuit Lifespan <12 Hours

CRRT sessions with a circuit lifespan of less than 12 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.

Other: Archived CRRT Device Log Data

CRRT Circuit Lifespan 12 to <24 Hours

CRRT sessions with a circuit lifespan of at least 12 hours but less than 24 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.

Other: Archived CRRT Device Log Data

CRRT Circuit Lifespan 24 to <48 Hours

CRRT sessions with a circuit lifespan of at least 24 hours but less than 48 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.

Other: Archived CRRT Device Log Data

CRRT Circuit Lifespan ≥48 Hours

CRRT sessions with a circuit lifespan of 48 hours or longer, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.

Other: Archived CRRT Device Log Data

Interventions

Archived CRRT Device Log Data OTHER

This observational study involves no assigned intervention, treatment, device use, or change in clinical care. The study analyzes archived pressure recordings from CRRT device log files generated during routine clinical care. The analyzed variables include access pressure, filter pressure, effluent pressure, return pressure, and transmembrane pressure. CRRT circuit lifespan is evaluated retrospectively according to the time between the first and last valid pressure recording. No additional procedures or study-related interventions are performed.

CRRT Circuit Lifespan 12 to <24 Hours; CRRT Circuit Lifespan 24 to <48 Hours; CRRT Circuit Lifespan <12 Hours; CRRT Circuit Lifespan ≥48 Hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult intensive care unit (ICU) patients who underwent continuous renal replacement therapy (CRRT) using the Prismaflex platform. Archived device log files (LOX format) generated during routine clinical care were evaluated. The unit of analysis was the individual CRRT session rather than the patient, as device logs were structured at the treatment-session level and patient-level linkage was not consistently available. Eligible sessions had a minimum runtime of 1 hour and at least 60 valid, chronologically ordered pressure recordings.

You may qualify if:

• Archived CRRT treatment sessions performed in adult intensive care unit patients.
• CRRT sessions recorded on the Prismaflex platform and available as LOX device log files.
• Sessions with a circuit lifespan of at least 1 hour, defined as the time between the first and last valid pressure recording.
• Sessions containing sufficient time-stamped pressure data for analysis, including at least 60 valid pressure measurements.
• Sessions with available pressure recordings for the relevant variables, including transmembrane pressure, access pressure, filter pressure, effluent pressure, and/or return pressure.
• Sessions with adequate data integrity and chronologically interpretable pressure records.

You may not qualify if:

• CRRT sessions with a runtime of less than 1 hour.
• Sessions with missing pressure tables.
• Sessions with fewer than 60 pressure measurements.
• Sessions with missing or incomplete primary device records.
• Sessions with missing timestamps or pressure records that cannot be ordered chronologically.
• Sessions with inadequate pressure-data density for trajectory analysis.
• Sessions with major data-integrity problems that prevent reliable calculation of circuit lifespan or pressure-derived variables.
• Duplicate or otherwise unusable device-log records.

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital

Yenimahalle, Ankara, 06200, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Critical Illness; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: anesthesiology specialist, M.D.

Study Record Dates

• First Submitted: September 21, 2026
• First Posted: September 25, 2026
• Study Start: September 20, 2026
• Primary Completion: September 20, 2026
• Study Completion: September 21, 2026
• Last Updated: September 25, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)