NCT07649785

Brief Summary

This experimental study investigates the acute cardiovascular and local recovery to a single session of resistance training, with and without additional static stretching, compared with a resting control condition. Participants are allocated to one of three groups (control, resistance training, resistance training plus static stretching) and assessed at baseline, immediately after the session, and 30 minutes post-exercise. Primary outcomes include rate-pressure product and local muscle oxygen saturation, while secondary outcomes include heart rate, blood pressure, brachial artery diameter, tissue hardness, and pressure pain threshold. These measures are used to characterize the short-term effects of the different experimental conditions on systemic hemodynamic load, vascular response, local muscle oxygenation, mechanical tissue status, and pressure pain sensitivity during early recovery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
28

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started Jan 2026

Shorter than P25 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 12, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 10, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 10, 2026

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

June 10, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 16, 2026

Completed
Last Updated

June 16, 2026

Status Verified

June 1, 2026

Enrollment Period

2 months

First QC Date

June 10, 2026

Last Update Submit

June 10, 2026

Conditions

Keywords

stretchingstatic stretchingrecoveryresistance trainingoxygenation

Outcome Measures

Primary Outcomes (2)

  • Rate-Pressure Product (RPP)

    Rate-pressure product (RPP) will be used as an index of myocardial workload and hemodynamic load during early post-exercise recovery. RPP will be calculated as heart rate multiplied by systolic blood pressure (Omron MX3 Plus). Heart rate and systolic blood pressure will be measured under standardized resting conditions at each time point.

    3 times (Baseline, immediately after intervantion and 30 minutes after intervention) for each condition (CC, RT, RT+ST)

  • Local Muscle Oxygen Saturation (SmO₂)

    Local muscle oxygen saturation (SmO₂) will be assessed using near-infrared spectroscopy (Moxy Monitor). The sensor will be positioned over the target muscle region and secured to minimize movement artifacts. SmO₂ will be recorded as a local index of the balance between oxygen delivery and oxygen utilization within the sampled muscle region.

    Time Frame: 3 times (Baseline, immediately after intervantion and 30 minutes after intervention) for each condition (CC, RT, RT+ST)

Secondary Outcomes (3)

  • Brachial Artery diameter

    Time Frame: 3 times (Baseline, immediately after intervention, and 30 minutes after intervention) for each condition (CC, RT, RT+SS)

  • Tissue Hardness (TH)

    Time Frame: 3 times (Baseline, immediately after intervention, and 30 minutes after intervention) for each condition (CC, RT, RT+SS)

  • Pain pressure Threshold(PPT)

    Time Frame: 3 times (Baseline, immediately after intervention, and 30 minutes after intervention) for each condition (CC, RT, RT+SS)

Study Arms (3)

RT

EXPERIMENTAL

Resistance Training

Other: Resistance Training

RT+SS

EXPERIMENTAL

Resistance Training + Static Stretching

Other: Resistance training + Static Stretching

Control Condition(CC)

NO INTERVENTION

participants sat silently on a chair without performing any train

Interventions

Participants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 100% of the individual's 8-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-25 minutes and does not include any additional static stretching beyond the standardized warm-up.

RT

Participants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 100% of the individual's 8-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-25 minutes .Immediately after the resistance exercises, they will complete a structured static stretching protocol targeting the trained muscle groups (pectoralis and elbow flexor), with each stretch held for about 30 seconds and repeated for several sets. The additional stretching lasts 12 minutes, for a total session duration of about 30-35 minutes.

RT+SS

Eligibility Criteria

Age18 Years - 55 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy male participants ≥ 18 years old

You may not qualify if:

  • orthopedic disorders
  • neurological disorders
  • metabolic disorders
  • cardovascular disorders

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Palermo

Palermo, Italy, 90144, Italy

Location

MeSH Terms

Interventions

Resistance TrainingMuscle Stretching Exercises

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Ewan Thomas, Associate Professor in Psychology, Educational Science and Human Movement

Study Record Dates

First Submitted

June 10, 2026

First Posted

June 16, 2026

Study Start

January 12, 2026

Primary Completion

March 10, 2026

Study Completion

March 10, 2026

Last Updated

June 16, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will not share

Locations