Stable Versus Unstable Resistance Training Effects on Physical Fitness and Physiological Biomarkers of Untrained Male University Students

NCT07349342 | Active Not Recruiting

• 1 other identifier: CNS-IRB/05/2015/2023
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn the effects of stable and unstable resistance training on physical fitness, kidney function and blood lipid tests in healthy young male volunteers. The main questions it aims to answer are:

• Do both stable and unstable resistance training increase the level of urinary protein clearance greater than the control group?
• What is the difference in improvement of lipid profiles among the groups?
• Does unstable resistance training mode rise muscular endurance greater than stable resistance training? Researchers will compare stable and unstable resistance training to see if there are differences on physical fitness measures, blood lipid and urinary protein tests. Participants, in their respective group will receive ten weeks of:
• Stable resistance training
• Unstable resistance training or
• No exercise training intervention

Conditions

No Condition; Health Young Males

Keywords

eGFR; urinary albumin to creatinine ratio; lipid profile; muscular strength; body composition; muscle; TRX

Outcome Measures

Primary Outcomes (14)

• Urinary Albumin

  * It will be measured using random urine samples in milligrams per liter * The minimum value is 0, the maximum is 20 * A higher score means a worse outcome

  At baseline and after 10 weeks of resistance training interventions

• Urinary Creatinine

  * It will be measured using random urine samples in millimoles per liter * The minimum value is 3, the maximum is 25. * A higher score means a better outcome

  At baseline and after 10 weeks of training intervention

• Urinary albumin to creatinine ratio

  * Urinary albumin to creatinine ratio is computed by dividing the obtained urinary albumin by urinary creatinine * It is measured in milligrams per millimole * The minimum value is 0, the maximum is 3 * A high score means a worse outcome

  At baseline and after 10 weeks of resistance training interventions

• Serum Creatinine

  * It is measured using a fasting blood sample in micromoles per liter * The minimum value is 50, the maximum is 110 * A higher score means a worse outcome

  At baseline and after 10 weeks of resistance training intervention

• Estimated Glomerular Filtration Rate

  * Estimated glomerular filtration rate is computed using a serum creatinine-based equation * The scores are reported in milliliters per minute per 1.73 square meters * The minimum value is 90, the maximum is 130 * A higher score means a better renal function

  At baseline and after 10 weeks of resistance training interventions

• High-Density Lipoprotein Cholesterol

  * It is measured using a fasting blood sample tests in millimoles per liter * The minimum value is 1, the maximum is greater than or equal to 2 * A higher score means a protective and better outcome

  At baseline and after 10 weeks of resistance training

• Low-Density Llipoprotein Cholesterol

  * It is measured using a fasting blood sample in millimoles per liter * The minimum value is 0, the maximum is 2.6 * A higher score means a worse outcome

  At baseline and after 10 weeks of resistance training

• Total Cholesterol

  * It is measured using a fasting blood sample test in millimoles per liter * The minimum score is 0, the maximum is 5.2 * A higher score means a worse outcome

  At baseline and after 10 weeks of resistance training

• Triglycerides

  * Triglycerides are measured using a fasting blood sample test in millimoles per liter * The minimum value is 0, the maximum is 1.7 * A higher score means a worse outcome

  At baseline and after 10 weeks of resistance training

• Hand Grip Strength

  * Hand grip strength test will be used to measure muscular strength * It is measured in kilograms * The minimum value is 27, the maximum is 56 * A higher score means a better outcome

  At baseline and after 10 weeks of training intervention

• Muscular Endurance

  * Push-up and sit-up tests will be used to measure muscular endurance * The number of repetitions is a unit for both tests * The minimum score for push-up is 20, the maximum is 40 * The minimum value for sit-up is 25, the maximum is 45 * A higher score means a better outcome

  At baseline and after 10 weeks of training intervention

• Core Endurance

  * The McGill core endurance test will be conducted and reported in seconds * The minimum value is 45, the maximum is 120 * A higher score means a better outcome

  At baseline and after 10 weeks of training intervention

• Flexibility

  * Sit and reach test will be conducted and reported in centimeters * The minimum value is 20, and the maximum is 35 * A higher score means a better outcome

  At baseline and after 10 weeks of training intervention

• Body Fat Percentage

  * It will be estimated using 3 site skin fold measures in millimeters * Body density will be calculated by the Jackson \& Pollock equation * The obtained density is converted into body fat percentage using the Sir equation * The minimum value is 10, the maximum is 22 * A higher score means aworse outcome

  At baseline and after 10 weeks of training intervention

Study Arms (3)

Unstable resistance training group

EXPERIMENTAL

Receiving total body resistance exercise (TRX) training intervention

Other: resistance training

Control group

NO INTERVENTION

no any structured exercise training intervention

stable resistance training group

EXPERIMENTAL

receiving traditional resistance training intervention

Other: resistance training

Interventions

resistance training OTHER

stable resistance training is represented by traditional resistance training using equipment like medicine ball, resistance machine and own body mass

stable resistance training group

Eligibility Criteria

• Age: 20 Years - 24 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• No resistance training within the previous six months
• Completing a written informed consent document
• Responding to the physical activity readiness questionnaire (PAR-Q) and becoming convenient

You may not qualify if:

• A history of musculoskeletal injury
• Chronic diseases, including known kidney disease
• A habit of alcohol or drug abuse

Sponsors & Collaborators

• Addis Ababa University: lead

Study Sites (1)

Kotebe University of Education

Addis Ababa, Yeka Sub City, Ethiopia

Location

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Aschenaki T Tessema, Ph.D.

  Addis Ababa University

  STUDY CHAIR

• Cherinet Z Zemela, MSc

  Kotebe University of Education

  PRINCIPAL INVESTIGATOR

• Zeru B Tola, Ph.D.

  Addis Ababa University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Participants were randomly assigned to a stable, unstable, and control group by computer software. All participants and the researcher know the assignment.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: This study employs a randomized pre-post-test experimental design with three groups. It involves a stable and unstable resistance training intervention for two training groups and a control group without training intervention but, advised to continue their regular daily routine.

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: January 16, 2026
• Study Start: November 12, 2025
• Primary Completion: February 1, 2026
• Study Completion: February 1, 2026
• Last Updated: January 16, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: beginning one year after publication and ending 2 years after the publication
• Access Criteria: data will be shared with reasonable request from any researcher who brings proposed analysis.

Locations

ET (1)