Assessment of Peripheral Neuropathy in Ankylosing Spondylitis

NCT07641920 | Not Yet Recruiting DMC

• 1 other identifier: Ankylosing.6.2026
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

investigators hypothesized that peripheral neuropathy in ankylosing spondylitis is associated with higher disease activity, greater central sensitization, worse functional impairment, and poorer quality of life.

Conditions

Ankylosing Spondylitis; Peripheral Neuropathies

Keywords

Ankylosing Spondylitis; Quality of Life; Peripheral Neuropathy

Outcome Measures

Primary Outcomes (1)

• presence of peripheral neuropathy

  Peripheral neuropathy will be evaluated using nerve conduction studies (NCS) for upper and lower limbs peripheral nerves performed according to standard electrophysiological techniques.

  1 month

Study Arms (1)

Ankylosing spondylitis Patients

Quality of Life Assessment By Ankylosing Spondylitis Quality of Life Questionnaire and Assessment of Peripheral Neuropathy using nerve conduction studies (NCS) for upper and lower limbs peripheral nerves performed according to standard electrophysiological techniques.

Diagnostic Test: Nerve conduction study

Interventions

Nerve conduction study DIAGNOSTIC_TEST

Peripheral neuropathy will be evaluated using nerve conduction studies (NCS) for upper and lower limbs peripheral nerves performed according to standard electrophysiological techniques.

Ankylosing spondylitis Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged ≥18 years with Diagnosis of ankylosing spondylitis according to the modified New York criteria

You may qualify if:

• Patients aged ≥18 years
• Diagnosis of ankylosing spondylitis according to the modified New York criteria (6).
• Ability to provide informed consent

You may not qualify if:

• Patients under the age of 18 years.
• Patients with definite diagnosis for any other systemic autoimmune disorders.
• Diabetes mellitus
• Chronic renal or hepatic disease
• Alcohol abuse or drug-induced neuropathy
• Known neurological disorders affecting peripheral nerves

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut university

Asyut, Asyut Governorate, 711111, Egypt

Location

Related Publications (2)

• Atik S, Sahin O, Atik I, Polat M. Neuropathic Pain Component in Patients with Ankylosing Spondylitis and the Relationship of Neuropathic Pain and Disease Activity Parameters: A Cross-Sectional Study. J Musculoskelet Neuronal Interact. 2024 Sep 1;24(3):284-290.

  PMID: 39219326 BACKGROUND

• Wu Q, Inman RD, Davis KD. Neuropathic pain in ankylosing spondylitis: a psychophysics and brain imaging study. Arthritis Rheum. 2013 Jun;65(6):1494-503. doi: 10.1002/art.37920.

  PMID: 23460087 BACKGROUND

MeSH Terms

Conditions

Spondylitis, Ankylosing; Peripheral Nervous System Diseases

Interventions

Nerve Conduction Studies

Condition Hierarchy (Ancestors)

Axial Spondyloarthritis; Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Ankylosis; Joint Diseases; Arthritis; Neuromuscular Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Officials

• Sara Farrag, Lecturer

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sara Farrag, Lecturer

CONTACT

+201097767735; sara_farrag@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Rheumatology and Rehabilitation

Study Record Dates

• First Submitted: June 8, 2026
• First Posted: June 11, 2026
• Study Start (Estimated): June 30, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: June 12, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)