NCT07383805

Brief Summary

  1. 1.To investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients and its correlation with disease activity and inflammatory markers.
  2. 2.Association of Tim-3 with sacroiliac MRI findings and the hip inflammatory MRI scoring system (HIMRISS) .

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
81

participants targeted

Target at P50-P75 for all trials

Timeline
40mo left

Started Jun 2026

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 16, 2026

Completed
18 days until next milestone

First Posted

Study publicly available on registry

February 3, 2026

Completed
4 months until next milestone

Study Start

First participant enrolled

June 1, 2026

Expected
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2029

Last Updated

February 3, 2026

Status Verified

January 1, 2026

Enrollment Period

3 months

First QC Date

January 16, 2026

Last Update Submit

January 26, 2026

Conditions

Ankylosing SpondylitisASTim3

Outcome Measures

Primary Outcomes (1)

  • To investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients

    investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients and its correlation with disease activity and inflammatory markers

    through study completion, an average of 1 year

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients diagnose as ankylosing spondylitis and healthy controls in Assiut university hospital

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assiut university

Asyut, University, Egypt

Location

MeSH Terms

Conditions

Spondylitis, Ankylosing

Condition Hierarchy (Ancestors)

Axial SpondyloarthritisSpondylarthropathiesSpondylarthritisSpondylitisSpinal DiseasesBone DiseasesMusculoskeletal DiseasesAnkylosisJoint DiseasesArthritis

Central Study Contacts

Eman Safwat, MD

CONTACT

01014116158safwateman605@gmail.com

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor

Study Record Dates

First Submitted

January 16, 2026

First Posted

February 3, 2026

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 1, 2029

Last Updated

February 3, 2026

Record last verified: 2026-01

Locations

EG(1)