NCT07639333|Recruiting
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
GRACE
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GRACE
Sponsor study identifier
Secondary identifiers
OTHER_GRANT · CHU Rennes
OTHER · ID-RCB
interventional
100
1 country
1
Study Start
September 11, 2026
Actual (reported)Primary Completion
March 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 5, 2026
Actual (reported)June 10, 2026
Actual (reported)September 11, 2026
Actual (reported)March 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Psychological distress score
HADS (Hospital Anxiety and Depression Scale) and PGS (Perinatal Grief Scale) scores. The impact of the NIPT results will be analyzed in relation to these scores, which will be combined into a composite score of psychological distress. HADS questionnaire : Each item is rated on a four-point scale, giving maximum scores of 21 for anxiety and depression. Scores of 11 or more on either subscale are considered to be a significant 'case' of psychological morbidity, while scores of 8-10 represents 'borderline' and 0-7 'normal' The PGS is a self-report questionnaire designed to assess the emotional and psychological impact of perinatal loss, including miscarriage, stillbirth, or neonatal death. The more the score is high, the more the grief is intense.
8 weeks
Long term Psychological distress score
12 months
Rate of balanced chromosomal abnormalities in a parent
8 weeks
Number of modified care pathways
12 months
Number of pregnancies
12 months
cell free fetal DNA analysis
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
CHU Rennes
Rennes, France
Marion Mercier, Md
Rennes University Hospital
Vincent LAVOUE, Pr
Rennes University Hospital
Sylvie JAILLARD
Rennes University Hospital
Erika LAUNAY
Rennes University Hospital
First Submitted
June 5, 2026
First Posted
June 10, 2026
Study Start
September 11, 2026
Actual (reported)Primary Completion
March 2028
EstimatedMachine Learning Miscarriage Management Clinical Decision Support Tool Study
Angular Pregnancy - Ultrasound Definition and Correlation With Clinical Outcomes
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 6, 2026
Record last verified: 2026-10
All of the individual participant data collected during the trial will be available, after the primary publication of the results, to any researchers who provide a methodologically sound proposal. Proposals should be directed to dri@chu-rennes.fr. To gain access, data requestors will need to sign a data access agreement; depending on the case, additional formalities may be required.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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