NCT06581692

Recruiting

Non-invasive Monitoring of Miscarriage

Chinese University of Hong Kong Source

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Other study identifiers

Sponsor study identifier

2024.354

Study Type

observational

Estimated enrollment

150

Locations

1 country

Sites

1

Timeline

Study Start

September 1, 2024

Actual (reported)

Primary Completion

August 31, 2039

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

August 31, 2039

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Brief Summary

cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test. This study aims to determine the level of cell-free DNA (cfDNA) in early pregnancy and compare the results with those of product of conception (POC) testing, in concordance with standard karyotyping.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: recruiting
Estimated enrollment: 150 participants
Study completion date: August 31, 2039
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
August 23, 2024
Actual (reported)
Study Start
September 1, 2024
Actual (reported)
First Posted
September 3, 2024
Actual (reported)
Primary Completion
August 31, 2039
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
August 31, 2039
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated: November 12, 2024
Status Verified: November 2024
Last Update Submitted: November 11, 2024

Conditions

Miscarriage in First Trimester

Outcome Measures

Primary Outcomes (1)

Cell-free DNA (cfDNA)
Determine the use of cfDNA to ascertain chromosomal causes of miscarriages
15 weeks

Secondary Outcomes (2)

Level of cell-free DNA
15 weeks
Aneuploidy results from product of conception
15 weeks

Interventions

This is a routine procedure, no intervention will be provided.Other

This is a routine procedure, no intervention will be provided.

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 45 Years

Sexall

Age GroupsAdult (18-64)

Sampling MethodProbability Sample

Study Population

Patients will be approached on the day of attending the early pregnancy loss clinic, and given information about the study. Sufficient time will be allowed for consideration before they confirm their decision and sign the consent. For cases with the management of ultrasound-guided manual vacuum aspiration (USG-MVA) or surgical evacuation, their remaining products of gestation will be collected for analysis.

You may qualify if:

Age 18-45 years.

Sponsors & Collaborators

Chinese University of Hong Kong
Otherlead

Study Sites (1)

Prince of Wales Hospital

Hong Kong, Hong Kong

RECRUITING

Jacqueline Pui Wah CHUNG, MBBSCONTACT30501537 jacquelinechung@cuhk.edu.hk

Biospecimen

Retention: SAMPLES WITH DNA

blood, Products of conception

Study Officials

PUI WAH JACQUELINE CHUNG
Chinese University of Hong Kong
PRINCIPAL INVESTIGATOR

Central Study Contacts

PUI WAH JACQUELINE CHUNG

CONTACT

+852 35051764 jacquelinechung@cuhk.edu.hk

Yee Lee Elaine NG

CONTACT

+852 35052745

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Associate Professor

Study Record Dates

First Submitted

August 23, 2024

First Posted

September 3, 2024

Study Start

September 1, 2024

Actual (reported)

Primary Completion

August 31, 2039

Estimated

NCT02957305

Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage

Phase 4Completed

NCT07639333

GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA

Not ApplicableRecruiting

NCT07160855

Letrozole Plus Misoprostol Versus Misoprostol Alone for Treating Women With Missed Miscarriage

Phase 4Recruiting

NCT06452719

Letrozole and Misoprostol for Early Pregnancy Loss Management

Phase 2Completed

NCT06986616

Fibroids and the Risk of Miscarriage: a Prospective Observational Study in an Early Pregnancy Population

Completed

NCT05516810

The Accuracy of Ultrasound Diagnosis of Hydatidiform Moles

Unknown

Women who attend the early pregnancy loss clinic or Patients who receive ART

Their partner, the biological father of the pregnancy

You may not qualify if:

History of psychological/ psychiatric problem
Patient refusal

Contact the study team to confirm eligibility.

elaineng@cuhk.edu.hk

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

August 31, 2039

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated

November 12, 2024

Record last verified: 2024-11

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT06581692
Data provider: ClinicalTrials.gov
Source updated: 2024-11-12
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:22:50 UTC

Locations

HK(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations