NCT07088510|RecruitingDMC
Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy
A Randomized Control Trial Investigating Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy
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Sponsor study identifier
interventional
80
1 country
1
Study Start
March 31, 2025
Actual (reported)Primary Completion
April 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Early pregnancy loss happens when a pregnancy that is not developing properly is found on an ultrasound before 12 weeks and 6 days. This type of loss occurs in about 10% of pregnancies. There are three main ways to treat this: waiting for it to pass naturally, using medication, or having surgery. Surgery is the most effective, working 99% of the time, compared to waiting (80% effective in 8 weeks) and medication (71-84% effective). Currently, surgery involves dilation of the cervix and curettage (removal of pregnancy tissue) with suction provided either from a manual hand-held pump or a machine. For the purposes of this study, a manual vacuum aspirator (or hand-held pump) will be used with ultrasound guidance. There is also another method called hysteroscopic resection, where the doctor uses a special camera to directly see and remove any pregnancy tissue from your uterus. Patients often want the quickest way to resolve the pregnancy loss, and physicians are unsure which surgical method is the best. It's also unclear if one type of surgery causes less scar tissue inside the uterus, affects the ability to test the tissue for genetic issues, or impacts how soon a patient can start fertility treatments again. This study aims to find out if hysteroscopic resection provides faster resolution and creates less scar tissue compared to the manual vacuum aspiration.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 31, 2025
Actual (reported)July 19, 2025
Actual (reported)July 28, 2025
Actual (reported)April 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change in beta human chorionic gonadotropin (bHCG) levels as measured by blood test
Baseline, 1 week post operation, 2 week post operation, 3 week post operation, 4 week post operation, 5 week post operation
Number of uterine adhesions detected by follow up hysteroscopy
4 weeks post operation
Number of post operative bleeding incidences as measured by nurse observation
Up to 1 hour post operation
Time in minutes to complete procedure
Up to 30 minutes
Number of retained products of conception as seen on follow up hysteroscopy
1 month post operation
Number of additional treatments needed as measured by follow up hysteroscopy
1 month post operation
Participants will undergo hysteroscopic resection of early pregnancy loss under monitored anesthesia care.
Participants will undergo manual vacuum aspiration of early pregnancy loss under monitored anesthesia care.
Participants will undergo a hysteroscopy where a camera is placed on the inside of the uterus. Then a resector will be used to remove the pregnancy loss under direct visualization.
Participants will undergo a manual vacuum aspiration with ultrasound guidance for treatment of early pregnancy loss. This is when pregnancy loss is suctioned by a machine from the uterus.
University Hospitals
Cleveland, Ohio, 44106, United States
Joseph Findley, MD
University Hospitals
Archana Ayyar, MD
University Hospitals
First Submitted
July 19, 2025
First Posted
July 28, 2025
Study Start
March 31, 2025
Actual (reported)Primary Completion
April 30, 2027
EstimatedManual Versus Electric Vacuum Aspiration for Pregnancy Termination Between 10-14 Weeks
Angular Pregnancy - Ultrasound Definition and Correlation With Clinical Outcomes
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 30, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 11, 2026
Record last verified: 2026-07
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Source: ClinicalTrials.gov.
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