3D Mapping Versus Conventional Ablation in AVNRT

NCT07630480 | Completed DMC

• 1 other identifier: AVNRT-3D-2025
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective randomized interventional study compared conventional fluoroscopy-guided slow pathway ablation versus three-dimensional electroanatomical mapping-guided ablation in patients with electrophysiologically confirmed typical atrioventricular nodal re-entrant tachycardia (AVNRT). A total of 108 patients were screened for eligibility, of whom 80 eligible patients were randomized in a 1:1 ratio to either conventional fluoroscopic ablation or 3D mapping-guided ablation. Following post-randomization dropouts, the final analysis included 38 patients in the conventional group and 36 patients in the 3D mapping group. The study evaluated fluoroscopy exposure, procedural efficacy, complete slow pathway elimination, procedural success, complications, and arrhythmia recurrence during follow-up.

Conditions

Supraventricular Tachycardia (SVT); Atrioventricular Nodal Reentry Tachycardia

Keywords

AVNRT; Catheter Ablation; Electrophysiology; Three-Dimensional Mapping; Electroanatomical Mapping; Fluoroscopy; Slow Pathway Ablation

Outcome Measures

Primary Outcomes (2)

• Total Fluoroscopy Radiation Dose During Catheter Ablation

  Total fluoroscopy radiation dose measured during the catheter ablation procedure, reported in mGy.

  At completion of the index ablation procedure

• Total Fluoroscopy Exposure Time During Catheter Ablation

  Total duration of fluoroscopy exposure during the catheter ablation procedure, reported in minutes.

  At completion of the index ablation procedure

Secondary Outcomes (2)

• Number of Participants With Complete Slow Pathway Elimination

  At completion of the index ablation procedure

• Number of Participants with Acute Procedural Success

  At completion of the index ablation procedure

Study Arms (2)

Conventional Fluoroscopy-Guided Ablation

ACTIVE COMPARATOR

Patients underwent conventional fluoroscopy-guided slow pathway ablation using standard anatomical landmarks and intracardiac electrogram criteria within the triangle of Koch.

Procedure: Conventional Slow Pathway Ablation

3D Electroanatomical Mapping-Guided Ablation

EXPERIMENTAL

Patients underwent three-dimensional electroanatomical mapping-guided slow pathway ablation using CARTO or EnSite X systems with integrated voltage, activation, and fractionated electrogram mapping.

Procedure: 3D Electroanatomical Mapping-Guided Ablation

Interventions

Conventional Slow Pathway Ablation PROCEDURE

Conventional fluoroscopy-guided catheter ablation of the slow AV nodal pathway using anatomical landmarks and intracardiac electrogram criteria within the triangle of Koch.

Also known as: Conventional Fluoroscopy-Guided Ablation

Conventional Fluoroscopy-Guided Ablation

3D Electroanatomical Mapping-Guided Ablation PROCEDURE

Three-dimensional electroanatomical mapping-guided catheter ablation of the slow AV nodal pathway using CARTO or EnSite X systems with voltage and activation mapping guidance.

3D Electroanatomical Mapping-Guided Ablation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Sustained symptomatic supraventricular tachycardia with surface ECG features highly suggestive of atrioventricular nodal re-entrant tachycardia (AVNRT).
• Electrophysiologically confirmed typical (slow-fast) AVNRT during the index electrophysiology study.
• Ability to provide written informed consent.

You may not qualify if:

• Coexisting arrhythmia requiring concurrent catheter ablation during the same procedure.
• Non-inducible AVNRT at the time of electrophysiological study.
• Antiarrhythmic drug use within 48 hours before the procedure or ongoing amiodarone therapy.
• Hemodynamic instability precluding safe catheter manipulation.
• Pregnancy.

Sponsors & Collaborators

• Kafrelsheikh University: lead

Study Sites (1)

Kafr Elsheikh Univfersity Hospital

Kafr ash Shaykh, Kafr el-Sheikh Governorate, 11355, Egypt

Location

MeSH Terms

Conditions

Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular

Condition Hierarchy (Ancestors)

Tachycardia, Reciprocating; Tachycardia; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcome assessment and follow-up evaluation were performed by investigators blinded to treatment allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer at cardiology department, Kafr Elsheikh University

Model Details: Eligible patients with electrophysiologically confirmed typical AVNRT were randomized in a 1:1 ratio to either conventional fluoroscopy-guided slow pathway ablation or three-dimensional electroanatomical mapping-guided ablation.

Study Record Dates

• First Submitted: May 23, 2026
• First Posted: June 5, 2026
• Study Start: December 30, 2023
• Primary Completion: November 23, 2025
• Study Completion: November 23, 2025
• Last Updated: June 5, 2026

Record last verified: 2026-06

Locations

EG (1)