European Multicenter Study RF Versus Cryo in AVNRT: A Randomized Study Comparing Cryo-Energy vs. Radiofrequency-Energy Ablation Technique for AV Nodal Reentry Tachycardia (AVNRT)
Sponsor study identifier
interventional
509
1 country
10
Study Start
March 2003
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
November 2008
Actual (reported)Study Completion
May 2009
Actual (reported)In this randomized study, two energy sources for the ablation of AV nodal reentry tachycardia are compared: The standard technique of radiofrequency energy delivery is compared with the new approach of cryo-energy application.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2009
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2003
Date type not reportedThis date has not been verified as actual or estimated.
September 13, 2005
Actual (reported)September 20, 2005
Actual (reported)November 2008
Actual (reported)May 2009
Actual (reported)Combined endpoint of safety and efficacy of cryo ablation compared with RF ablation for procedure and 6 months follow-up data.
6 months
RF ablation/modulation of the slow pathway in AV nodal reentrant tachycardia
cryo energy ablation/modulation of the slow pathway in AV nodal reentrant tachycardia
RF ablation/modulation of the slow pathway in AV nodal reentrant tachycardia
Cryo ablation/modulation of the slow pathway in AV nodal reentrant tachycardia
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Kerckhoffklinik GmbH EPU
Bad Nauheim, 61231, Germany
Charite Berlin Virchow - Klinikum Med. Klinik
Berlin, 13353, Germany
Universitaetsklinikum Bonn Med. Klinik II
Bonn, 53105, Germany
Evangelisches Krankenhaus Duesseldorf Kardiologie
Düsseldorf, 40217, Germany
Universitaetsklinikum Giessen EPU
Giessen, 35392, Germany
Klinikum Luedenscheid Kardiologie
Lüdenscheid, 58515, Germany
Klinikum der Stadt Mannheim Med. Klinik I
Mannheim, 68167, Germany
Deisenhofer I, Zrenner B, Yin YH, Pitschner HF, Kuniss M, Grossmann G, Stiller S, Luik A, Veltmann C, Frank J, Linner J, Estner HL, Pflaumer A, Wu J, von Bary C, Ucer E, Reents T, Tzeis S, Fichtner S, Kathan S, Karch MR, Jilek C, Ammar S, Kolb C, Liu ZC, Haller B, Schmitt C, Hessling G. Cryoablation versus radiofrequency energy for the ablation of atrioventricular nodal reentrant tachycardia (the CYRANO Study): results from a large multicenter prospective randomized trial. Circulation. 2010 Nov 30;122(22):2239-45. doi: 10.1161/CIRCULATIONAHA.110.970350. Epub 2010 Nov 15.
Claus Schmitt, MD
Deutsches Herzzentrum Muenchen
Bernhard Zrenner, MD
Deutsches Herzzentrum Muenchen
509 participants (actual enrollment reported by the registry).
First Submitted
September 13, 2005
First Posted
September 20, 2005
Study Start
March 2003
Date type not reportedThis date has not been verified as actual or estimated.
Intracardiac Echocardiography Guided Slow Pathway Cryoablation
Contact the study team to confirm eligibility.
Deutsches Herzzentrum Muenchen
Munich, 80636, Germany
Universitaetsklinikum Tuebingen Med. Klinik/Abt.III
Tübingen, 72076, Germany
Universitaetsklinikum Ulm Innere Med. II
Ulm, 89075, Germany
Primary Completion
November 2008
Actual (reported)Study Completion
May 2009
Actual (reported)Last Updated
July 4, 2013
Record last verified: 2013-07
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Source: ClinicalTrials.gov.
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