Within-Individual Variability of Resting Metabolic Rate Over 12 Weeks

NCT07628764 | Not Yet Recruiting

• 1 other identifier: 0012137-2
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions. Participants will undergo RMR assessments three times per week using whole-room indirect calorimetry. The study will quantify the magnitude of physiological variability in RMR, distinguish true biological variation from measurement error, and estimate the minimal detectable change required to identify meaningful metabolic adaptations.

Conditions

Resting Metabolic Rate; Energy Metabolism

Keywords

Resting Metabolic Rate; Energy Expenditure; Metabolism; Indirect Calorimetry; Variability

Outcome Measures

Primary Outcomes (1)

• Within-Individual Variability in Resting Metabolic Rate (RMR)

  Within-individual variability in resting metabolic rate (RMR) assessed using repeated measurements under standardized conditions. Variability will be quantified using mean, standard deviation (SD), and coefficient of variation (CV%) across repeated measurements.

  12 weeks

Secondary Outcomes (3)

• Minimal Detectable Change (MDC) in RMR

  12 weeks

• Between-Individual Variability in RMR

  12 weeks

• Temporal Trends in RMR

  12 weeks

Study Arms (1)

Healthy Adults

Healthy adult participants undergoing repeated measurements of resting metabolic rate (RMR) three times per week over a 12-week period under standardized conditions. No intervention is applied.

Other: Repeated Measurement of Resting Metabolic Rate

Interventions

Repeated Measurement of Resting Metabolic Rate OTHER

Repeated assessment of resting metabolic rate under standardized conditions; no intervention is administered.

Healthy Adults

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adult men and women from the community, aged 18-65 years, who are clinically healthy and able to participate in repeated metabolic measurements under standardized laboratory conditions.

You may qualify if:

• Adults aged 18-65 years
• Clinically healthy individuals
• Stable body weight (±2 kg) over the past 3 months
• Ability and willingness to attend morning measurements three times per week for 12 weeks
• Ability to provide informed consent

You may not qualify if:

• Known uncontrolled endocrine or metabolic disease
• Use of medications known to significantly affect resting metabolic rate (e.g., systemic corticosteroids, unstable thyroid hormone therapy)
• Acute illness within 14 days prior to enrollment
• Pregnancy or lactation
• Any medical condition that, in the opinion of the investigators, may interfere with safe participation

Sponsors & Collaborators

• Tel Aviv University: lead

Study Officials

• Yftach Prof. Gepner

  Tel Aviv University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yftach Prof. Gepner

CONTACT

+972 50-682-8501; gepner@tauex.tau.ac.il

Lien Bruck

CONTACT

+972 587487431

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator - Professor

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 5, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: June 5, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share