NCT07594613

Brief Summary

This study examines whether resting metabolic rate (RMR)-the amount of energy the body uses at rest-is similar between biological parents and their adult children (aged 18 years and older). RMR is the largest component of daily energy expenditure and plays an important role in body weight regulation and overall metabolic health. Participants from the same family will undergo a single testing session in a metabolic laboratory. RMR will be measured using indirect calorimetry under standardized conditions, along with body composition assessment and basic health information. The primary goal is to determine whether RMR is correlated within families. The study will also assess whether these similarities remain after accounting for differences in body composition, age, and sex. This observational study will help improve understanding of how metabolism varies between individuals and the extent to which these differences may be influenced by familial or inherited factors. Findings may contribute to future research on personalized nutrition, obesity risk, and metabolic health.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
12mo left

Started Jun 2026

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 13, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 19, 2026

Completed
13 days until next milestone

Study Start

First participant enrolled

June 1, 2026

Expected
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2027

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2027

Last Updated

May 19, 2026

Status Verified

May 1, 2026

Enrollment Period

1 year

First QC Date

May 13, 2026

Last Update Submit

May 13, 2026

Conditions

Resting Metabolic RateMetabolism Disorders

Keywords

Resting metabolic rateEnergy expenditureHeritabilityBody compositionmetabolic disorder

Outcome Measures

Primary Outcomes (1)

  • Parent-Offspring Correlation in Resting Metabolic Rate

    Correlation coefficient (Pearson or Spearman) between resting metabolic rate (RMR) measured in biological parents and their adult children using indirect calorimetry.

    Single study visit (baseline assessment)

Secondary Outcomes (3)

  • Adjusted Association Between Parent and Offspring Resting Metabolic Rate

    Single study visit (baseline)

  • Sex-Specific Parent-Offspring Correlation in Resting Metabolic Rate

    Single study visit (baseline)

  • Within-Family Variability in Resting Metabolic Rate

    Single study visit (baseline)

Study Arms (1)

Parent-Adult Child Families

Biological parents (aged 40-60 years) and their adult children (≥18 years) participating in a single study visit. All participants undergo resting metabolic rate measurement using indirect calorimetry and body composition assessment under standardized laboratory conditions. Parent-offspring pairs are analyzed to assess familial patterns in metabolic rate.

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Biological parent-adult child families recruited from the general population. Participants are generally healthy adults, including parents aged 40-60 years and their adult children aged 18 years and older, without known metabolic disorders.

You may qualify if:

  • Biological parent-adult child pairs
  • Adult children aged ≥18 years
  • Parents aged 40-60 years
  • Ability to comply with study procedures, including fasting and resting conditions
  • Generally healthy individuals without acute illness

You may not qualify if:

  • Current weight loss or active dieting
  • Known metabolic disorders (e.g., thyroid disease)
  • Use of medications affecting metabolic rate
  • Pregnancy
  • Acute illness at the time of testing
  • Inability to comply with pre-test requirements (e.g., fasting, avoiding exercise or caffeine)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sylvan Adams Sport Science Institute

Tel Aviv, Israel

Location

MeSH Terms

Conditions

Metabolic Diseases

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Central Study Contacts

Yftach Prof. Gepner

CONTACT

0506828501gepner@tauex.tau.ac.il

Lien Bruck

CONTACT

0587487431lienbruck@tauex.tau.ac.il

Study Design

Study Type
observational
Observational Model
FAMILY BASED
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator - Professor

Study Record Dates

First Submitted

May 13, 2026

First Posted

May 19, 2026

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

June 1, 2027

Study Completion (Estimated)

June 1, 2027

Last Updated

May 19, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations

IL(1)