Correlation Analysis of Gene Characteristics of Malignant Tumors With Prognosis

NCT07622667 | Recruiting

• 1 other identifier: NFEC-2026-090
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a single-center observational investigation aimed at systematically exploring the key molecular features influencing the prognosis of malignant tumors by integrating multidimensional clinical information with multi-omics molecular data. The goal is to provide a critical scientific basis for constructing precise prognostic prediction models, identifying potential therapeutic targets, and optimizing clinical treatment strategies. The study plans to consecutively enroll adult patients with histologically confirmed malignant tumors who received antitumor therapy at our hospital between January 2017 and December 2025. Clinical data (including demographic characteristics, tumor pathology information, treatment histories, and survival follow-up data) will be systematically collected from electronic medical records. Additionally, tumor tissue or blood samples will be obtained from the patients for sequencing, staining, ELISA, drug sensitivity testing, and flow cytometry analysis to comprehensively characterize the genomic features, immune microenvironment, and cellular heterogeneity of the tumors.

Conditions

Malignant Tumors

Outcome Measures

Primary Outcomes (1)

• Overall Survival (OS)

  The time from the start of treatment to death from any cause. Patients who are alive at the last follow-up are censored.

  From date of treatment initiation until date of death or last follow-up, assessed up to 5 years.

Secondary Outcomes (3)

• Progression-Free Survival (PFS)

  From date of treatment initiation until date of progression or death, assessed up to 5 years.

• Pathological Complete Response (pCR)

  At the time of surgery following neoadjuvant treatment, typically within 4-6 weeks after completion of therapy.

• Major Pathologic Response (MRP)

  At the time of surgery following neoadjuvant treatment, typically within 4-6 weeks after completion of therapy.

Study Arms (3)

Immunotherapy Group

Drug: Immunotherapy Therapy

Radiotherapy Group

Radiation: Radiation Therapy

Surgery Group

Procedure: Radical surgery

Interventions

Immunotherapy Therapy DRUG

Patients receiving immunotherapies such as immune checkpoint inhibitors. Immunotherapy can be administered as first-line or subsequent treatment, or as part of combination therapy, integrated with modalities such as surgery, chemotherapy, radiotherapy, and targeted therapy.

Immunotherapy Group

Radiation Therapy RADIATION

Patients for whom radiotherapy is the primary or a significant component of their treatment. Radiotherapy may be administered with curative, adjuvant, or palliative intent, and can be given alone or in combination with surgery, chemotherapy, targeted therapy, immunotherapy, etc.

Radiotherapy Group

Radical surgery PROCEDURE

Patients undergoing curative tumor resection as their primary treatment modality. Surgery may be performed with or without neoadjuvant/adjuvant chemotherapy, radiotherapy, targeted therapy, or immunotherapy.

Surgery Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with pathologically confirmed malignant tumors.

You may qualify if:

• Voluntarily sign the informed consent form.
• Treated at Nanfang Hospital, Southern Medical University between January 2017 and December 2025.
• Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2.
• Availability of surplus routinely discarded clinical tumor tissue samples (biopsy specimens or pathological sections) or blood samples for assays such as sequencing, staining, ELISA, drug sensitivity testing, and flow cytometry.

Sponsors & Collaborators

• Nanfang Hospital, Southern Medical University: lead
• Chia Tai Tianqing Pharmaceutical Group Co., Ltd.: collaborator

Study Sites (1)

Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, China

RECRUITING

Related Publications (10)

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MeSH Terms

Conditions

Neoplasms

Interventions

Radiotherapy

Intervention Hierarchy (Ancestors)

Therapeutics

Central Study Contacts

Wei Wang Wang

CONTACT

02061642135; 29262574@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 28, 2026
• First Posted: June 3, 2026
• Study Start: May 29, 2026
• Primary Completion (Estimated): January 30, 2027
• Study Completion (Estimated): June 30, 2027
• Last Updated: June 3, 2026

Record last verified: 2026-05

Locations

CN (1)