Frailty and Severity as Determinants of Hospital Cost in the ICU

NCT07621276 | Completed DMC

• 1 other identifier: H+QRO-2026-FRAILTY
• Study Type: observational
• Target: 142
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated the association between baseline frailty (mFI-11) and acute illness severity (SAPS 3) with real hospital costs in adult patients admitted to the Intensive Care Unit (ICU). The objective was to determine if frailty and severity are independent predictors of resource consumption.

Conditions

Frailty; Critical Illness; Hospital Costs

Keywords

Intensive Care Unit; SAPS 3; mFI-11; Resource Allocation; Critical

Outcome Measures

Primary Outcomes (1)

• Total Real Hospital Cost

  The total monetary expenditure (in local currency) recorded in the institutional administrative database for the hospital episode, from admission to discharge or death.

  From ICU admission to hospital discharge (approximately 17 months of data collection period).

Study Arms (1)

ICU Patient Cohort

All adult patients (≥18 years) admitted to the ICU during the study period with complete medical and financial records.

Other: Total Real Hospital Cost.

Interventions

Total Real Hospital Cost. OTHER

The total monetary expenditure (expressed in Mexican Pesos) generated during the hospital stay, as recorded in the institutional financial database.

ICU Patient Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pacientes adultos (≥18 años) admitidos a la Unidad de Cuidados Intensivos del Hospital H+ Querétaro entre el 1 de enero de 2024 y el 31 de mayo de 2025. Se incluirán únicamente aquellos con expedientes clínicos completos que permitan el cálculo del índice de fragilidad modificado de 11 ítems (mFI-11), el puntaje de severidad SAPS 3 y el índice de comorbilidad de Charlson, así como disponibilidad de registros institucionales de costos hospitalarios reales. Se excluirán pacientes con información incompleta en variables principales, transferidos de otras instituciones sin datos basales suficientes, con inconsistencias significativas en los registros de costos, o reingresos en los que no sea posible atribuir de manera independiente los costos al episodio índice.

You may qualify if:

• Patients aged 18 years or older.
• Admission to the ICU between January 1, 2024, and May 31, 2025.
• Complete medical records allowing for the calculation of mFI-11, SAPS 3, and Charlson Index.

You may not qualify if:

• Incomplete records for primary exposure or outcome variables.
• Patients transferred from other institutions without sufficient baseline data.
• Severe inconsistencies in cost records.
• Subsequent readmissions where costs cannot be independently attributed to the index episode.

Sponsors & Collaborators

• Hospital H+ Queretaro: lead

Study Sites (1)

Hospital H+ Querétaro, Santiago de Querétaro, Querétaro

Querétaro City, Querétaro, 7600, Mexico

Location

MeSH Terms

Conditions

Frailty; Critical Illness

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Disease Attributes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 17 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Efrain Aguila Velazquez Martinez

Study Record Dates

• First Submitted: May 27, 2026
• First Posted: June 2, 2026
• Study Start: January 1, 2024
• Primary Completion: May 31, 2025
• Study Completion: June 1, 2025
• Last Updated: June 2, 2026

Record last verified: 2026-05

Locations

ME (1)