CALLY Index, Frailty and SOFA-2 for Mortality Prediction in Geriatric ICU Patients

NCT07579728 | Recruiting

• 1 other identifier: KAEK/04.02.2026.82
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index, Clinical Frailty Scale (CFS), and SOFA-2 score in predicting mortality among geriatric intensive care unit (ICU) patients. The primary outcome is ICU mortality. Secondary outcomes include 28-day mortality, ICU length of stay, duration of mechanical ventilation, need for renal replacement therapy, and vasopressor requirement. The study also investigates whether the combined use of these parameters improves predictive performance compared to conventional scoring systems such as APACHE II.

Conditions

Critical Illness; Frailty; Intensive Care Unit (ICU)

Keywords

CALLY index; frailty; SOFA-2 score; ICU mortality; Geriatric patients

Outcome Measures

Primary Outcomes (1)

• ICU Mortality

  All-cause mortality occurring during the intensive care unit stay.

  From ICU admission until ICU discharge or death, assessed up to 28 days

Secondary Outcomes (6)

• 28-day Mortality

  28 days

• ICU Length of Stay

  From ICU admission until ICU discharge or death, assessed up to 28 days

• Hospital Length of Stay

  From hospital admission until hospital discharge or death, assessed up to 28 days

• Duration of Mechanical Ventilation

  From initiation of invasive mechanical ventilation until discontinuation, assessed up to 28 days

• Vasopressor Requirement

  From ICU admission until ICU discharge or death, assessed up to 28 days

Study Arms (1)

Geriatric ICU patients

Geriatric patients (aged ≥65 years) admitted to the intensive care unit will be included as a single observational cohort. All participants will be evaluated for CALLY index, frailty status, and SOFA-2 score within the first 24 hours of ICU admission.

Other: observational study

Interventions

observational study OTHER

No intervention is applied.This is an observational study in which patients receive standart clinical care.

Geriatric ICU patients

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Geriatric patients (aged ≥65 years) admitted to the intensive care unit.

You may qualify if:

• Age ≥65 years
• Admission to the intensive care unit
• Availability of required clinical and laboratory data within the first 24 hours of ICU admission

You may not qualify if:

• Death within the first 24 hours after ICU admission
• Missing key clinical or laboratory data
• Terminal malignancy receiving palliative care

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Başakşehir Çam and Sakura City Hospital

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Critical Illness; Frailty

Interventions

Observation

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Central Study Contacts

TUGBA Yesilyurt Dogu, MD

CONTACT

+905535150847; tugbaayesilyurt@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist in Anesthesiology and Intensive Care

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: May 12, 2026
• Study Start: April 30, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): July 10, 2026
• Last Updated: May 12, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)