Human Neural Correlates of Multi-Timescale Inference

NCT07606469 | Not Yet Recruiting

• 2 other identifiers: 25-1284R00NS127855
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.

Conditions

Brain Activity; Cognition

Outcome Measures

Primary Outcomes (3)

• Pupil size changes with respect to task features

  pupil size will be measured with a portable eye-tracking device and correlated with task features

  continuous recording during task, up to 30 minutes

• Behavioral Responses

  Patient selects one of two choices on each trial using the computer keyboard

  Approximately 10 seconds per trial, up to 30 minutes total

• Intracranial electrode recordings to measure changes in brain activity during decision making

  Intracranial neural recordings from patients who are implanted with electrodes for clinical purposes tha take place during the decision-making task

  duration of the task, approximately 30 minutes

Study Arms (1)

Flexible Decision Making Task

Behavioral: Decision-making task; Behavioral: eye tracking

Interventions

Decision-making task BEHAVIORAL

Patients will be asked to play a decision-making game in which they hear a tone and must identify its source.

Flexible Decision Making Task

eye tracking BEHAVIORAL

Patients will have simultaneous eye-tracking performed while playing the decision-making game

Flexible Decision Making Task

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Epilepsy patients with intractable seizures who are undergoing clinical continuous intracranial recordings of the brain's electrical activity to assess the seizure focus location.

You may qualify if:

• Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.
• no lesions identified in the participants' brains
• capable of giving consent

You may not qualify if:

• seizure activity during task recording
• electrodes in regions of interest are identified to be the seizure focus
• task performance outside of the normal range as determined from online studies with healthy participants

Sponsors & Collaborators

• University of Colorado, Boulder: lead

Study Sites (1)

University of Colorado Anschutz

Aurora, Colorado, 80045, United States

Location

Central Study Contacts

Tahra Eissa

CONTACT

(303) 492-6974; tahra.eissa@cuanschutz.edu

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 11, 2026
• First Posted: May 26, 2026
• Study Start: June 15, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): June 30, 2028
• Last Updated: May 26, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)