Neurocognitive Correlates of the Influence of Number Word Syntax on Magnitude Processing

NCT07133230 | Not Yet Recruiting

• 1 other identifier: D24-P010
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words. participant investigate the neurofunctional correlates of the syntactic processing of number words by examining different levels of place-value processing in a study with two complementary successive phases (Group 1 and Group 2) in healthy adults. In the first phase with Group 1, participant evaluate the unit-decade compatibility effect (UDCE) in two-digit magnitude comparisons. In the second phase with Group 2, participant investigate the carry-over effect in two-digit addition problems.

Conditions

Brain Activity

Outcome Measures

Primary Outcomes (4)

• Neurofunctional variables (fMRI)

  the comparison of pairs of incompatible numbers compared to pairs of compatible numbers during the comparison of numbers.

  Day 1

• Structural variables (structural MRI)

  the comparison of problems of addition with and without restraint during mental arithmetic.

  Day 1

• Behavioral variables,

  we compare performance to the post-imaging reading test

  Day 1

• structural variables

  recording of morphological and brain morphometric characteristics.

  Day 1

Secondary Outcomes (2)

• Handedness score

  Day 1

• Demographics questionnaire

  Day 1

Study Arms (2)

Participants recruited (phase 1)

In each experimental phase (2 in total), 42 adult volunteers will be recruited (a total of 84 participants), selected based on the following criteria: * Aged 18-45 * Female or male * Right-handed * Signed informed consent * Normal medical, neurological, and neuroradiological examinations * Affiliated with a social security system * For women of childbearing age: under effective contraception; a urine pregnancy test will be administered * MRI examination compatible Participants will be recruited in the Paris region.

Participants recruited (phase 2)

In each experimental phase (2 in total), 42 adult volunteers will be recruited (a total of 84 participants), selected based on the following criteria: * Aged 18-45 * Female or male * Right-handed * Signed informed consent * Normal medical, neurological, and neuroradiological examinations * Affiliated with a social security system * For women of childbearing age: under effective contraception; a urine pregnancy test will be administered * MRI examination compatible Participants will be recruited in the Paris region.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

In the experimental phase, 42 adult volunteers (a total of 84), selected according to strict criteria, will undergo an MRI scan, each comprising: - anatomical acquisition, - functional acquisition of activation during a number processing task (Phase 1: two-digit number magnitude comparison; Phase 2: multi-digit mental arithmetic).

You may qualify if:

• Subject aged 18 to 45 years;
• Female or male;
• Right-handed preference;
• Subject, or legal representative, who has given consent to participate;
• Native language: French
• Subject affiliated with a social security system;
• Having signed their consent to participate (and their legal representative if applicable),
• Subjects have read the information letter and given their free and informed consent;
• Normal medical, neurological, and neuroradiological examinations
• For women of childbearing age, be on effective contraception

You may not qualify if:

• Not corresponding to the targeted age range;
• Subject with contraindications to an MRI examination (pacemaker or neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign bodies in the eyes or brain near neural structures, metal prostheses, patient agitation: non-cooperative or agitated patients, minors, claustrophobic subjects, pregnant women, ventriculoperitoneal neurosurgical shunt valves, dental braces);
• Subject with chronic alcohol or drug use;
• Abuse or dependence on substances (except nicotine) or toxic substances for more than 5 years or having led to comas (overdoses);
• Subject with sudden-onset cognitive disorders that could indicate a stroke; a history of head trauma with loss of consciousness for more than 1 hour, or encephalitis;
• Subject with chronic neurological, psychiatric, endocrine, hepatic, or infectious conditions;
• Subject with a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrine, or immunological disorder, cancer);
• Subject on medication: taking medications likely to interfere with brain imaging measurements (psychotropics, anxiolytic hypnotics, neuroleptics, anti-Parkinsonians, benzodiazepines, steroidal anti-inflammatories, antiepileptics, central analgesics, and muscle relaxants);
• Color blindness;
• Inability to comply with the study for geographical or psychiatric reasons;
• Tattoo incompatible with MRI;
• Cerebral palsy;
• Fine motor skills disorder;
• Adult subjects under legal protection or unable to give consent (article L.1121-8 of the French Public Health Code) (under guardianship or curatorship);
• Children and parents under legal protection measures

Sponsors & Collaborators

• Centre Hospitalier St Anne: lead

Study Sites (1)

GHU Ste Anne

Paris, 75014, France

Location

Central Study Contacts

Elise Klein

CONTACT

+49 175 2042210‬; elise.klein@u-paris.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 12, 2025
• First Posted: August 20, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 30, 2027
• Last Updated: August 20, 2025

Record last verified: 2025-05

Locations

FR (1)