Immune and Cognitive Benefits of Mango Intake in Young Adults

NCT06229262 | Not Yet Recruiting

• 1 other identifier: 5230334
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30 years

Conditions

Cognition; Immunity

Keywords

Mango; Immunity; cognition

Outcome Measures

Primary Outcomes (6)

• Changes in lymphocyte populations

  Immunophenotyping will be performed by flow cytometry to measure the number of T helper, T cytotoxic, Naive and memory cells and B cells

  baseline to 12 weeks

• Changes in Lymphocyte activity

  The production of lymphocytes will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)

  baseline to 12 weeks

• Changes in cytokine production

  The cytokines produced due to lymphocyte activity will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)

  baseline to 12 weeks

• Changes in serum inflammatory cytokine concentration

  changes in the concentrations of the inflammatory cytokines will be performed on serum using enzyme linked immunoassay (ELISA) will include hs-CRP, interleukin (IL)-1B, IL-6, TNF a, IL-10, IL-2, IFN-γ, E-selectin,

  baseline to 12 weeks

• changes from baseline in global cognitive composite score

  The composite score will be calculated using the scores from the tests listed below. Scores will be calculated with the standardized scores of each test as the score of each participant minus the group mean and divide by its standard deviation. The composite score is the mean of the standardized scores. the 5 tests are: Rey Auditory Verbal Learning Test (RAVLT), Brief Visuospatial Memory Test, Digit Span, FAS Word Fluency, Symbol Digit Modalities Test

  baseline to 12 weeks

• Change in serum brain-derived neurotrophic factor (pg/mL)

  changes in serum brain-derived neurotrophic factor (pg/mL) assessed by ELISA

  baseline to 12 weeks

Study Arms (2)

Mango Group

ACTIVE COMPARATOR

Participants in the Mango group will consume 1.5 cups of mangos for 12 weeks

Dietary Supplement: Mango group

control group

NO INTERVENTION

The control group will receive no dietary intervention. they will follow usual diet and abstain from eating mangos

Interventions

Mango group DIETARY_SUPPLEMENT

Participants will consume 1.5 cups of mangos per day for 12 weeks.

Mango Group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male and female college students aged 18-30 years

You may not qualify if:

• known intolerance or allergy to mangos
• regular intake of mangos and/or fruits of a similar nutritional content such as peach, nectarine, papaya, apricot and cantaloupe
• using cognition and/or immune-boosting supplements or vitamins
• recent exposure to antibiotics and corticoids
• uncontrolled chronic diseases and mental illnesses, clinical depression, and immunocompromised state

Sponsors & Collaborators

• Loma Linda University: lead
• National Mango Board: collaborator

Study Sites (1)

Loma Linda University School of Public Health

Loma Linda, California, 92350, United States

Location

Study Officials

• Sujatha Rajaram, PhD

  Loma Linda University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sujatha Rajaram, PhD

CONTACT

909-558-4300; srajaram@llu.edu

Amandeep Wright, MPH

CONTACT

909-558-4300; amawright@llu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The investigator and outcome assessor will not be aware of which participant is in which arm
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: this will be a12 week, parallel study , free living with college going young adults aged 18-30 years

Study Record Dates

• First Submitted: January 19, 2024
• First Posted: January 29, 2024
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: January 30, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)