Multi-Ingredient Supplementation in Professional Football Players

NCT07604519 | Not Yet Recruiting

• 1 other identifier: MIZERA-FOOTBALL-2026
• Study Type: interventional
• Target: 100
• Locations: 3 countries
• Sites: 5

Brief Summary

This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite male soccer players. Participants will complete a 14-day supplementation protocol and undergo football-specific performance, reaction-time, cognitive-fatigue, recovery, and sleep-related assessments before and after the intervention. The study aims to determine whether phosphatidylserine dose influences physical, cognitive, fatigue-related, and recovery-related outcomes when combined with taurine and caffeine.

Conditions

Sports Performance; Cognitive Performance During Physical Activity; Fatigue; Recovery; Football Players

Keywords

Soccer; Football; Supplementation; Exercise Performance; Recovery

Outcome Measures

Primary Outcomes (1)

• 30 m sprint time

  Time required to complete a 30 m sprint, measured using electronic timing gates. The best result from three maximal sprint trials will be used for analysis. Unit of Measure: seconds

  Baseline and after 14 days of supplementation

Secondary Outcomes (17)

• Fatigue-related sprint decline

  After 14 days of supplementation, during the standardized football-specific training session

• Visual reaction time

  Baseline and after 14 days of supplementation

• Auditory reaction time

  Baseline and after 14 days of supplementation

• Total distance covered

  After 14 days of supplementation, during the standardized football-specific training session

• Relative distance

  After 14 days of supplementation, during the standardized football-specific training session

Study Arms (4)

P

PLACEBO COMPARATOR

Participants will receive visually identical placebo capsules for 14 days.

Other: Placebo

TC

EXPERIMENTAL

Participants will receive taurine (1500 mg/day) and caffeine (200 mg/day) supplementation for 14 days.

Dietary Supplement: taurine; Dietary Supplement: Caffeine

TCP-300

EXPERIMENTAL

Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (300 mg/day) supplementation for 14 days.

Dietary Supplement: taurine; Dietary Supplement: Caffeine; Dietary Supplement: Phosphatidylserine

TCP-600

EXPERIMENTAL

Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (600 mg/day) supplementation for 14 days.

Dietary Supplement: taurine; Dietary Supplement: Caffeine; Dietary Supplement: Phosphatidylserine

Interventions

Placebo OTHER

Placebo capsules administered daily during the 14-day intervention period

P

taurine DIETARY_SUPPLEMENT

Taurine supplementation administered daily during the 14-day intervention period.

TC; TCP-300; TCP-600

Caffeine DIETARY_SUPPLEMENT

Caffeine supplementation administered daily during the 14-day intervention period.

TC; TCP-300; TCP-600

Phosphatidylserine DIETARY_SUPPLEMENT

Phosphatidylserine supplementation administered daily during the 14-day intervention period.

TCP-300; TCP-600

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Professional male football players aged 18-35 years
• Regular participation in team training and competitive matches
• Clinically healthy status confirmed prior to participation
• Written informed consent provided

You may not qualify if:

• Current musculoskeletal injury or illness
• Chronic metabolic, cardiovascular, or neurological disease
• Regular medication use
• Current use of dietary supplements or ergogenic aids
• Smoking or excessive alcohol consumption
• Known hypersensitivity to any study supplement ingredient

Sponsors & Collaborators

• Vizja University in Warsaw: lead

Study Sites (5)

Professional Football Training Center

Budapest, Hungary

Location

Professional Football Training Center

Lodz, Poland

Location

Professional Football Training Center

Warsaw, Poland

Location

Professional Football Training Center

Wroclaw, Poland

Location

Professional Football Training Center

Alicante, Spain

Location

MeSH Terms

Conditions

Fatigue

Interventions

Taurine; Caffeine; Phosphatidylserines

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Alkanesulfonic Acids; Alkanes; Hydrocarbons, Acyclic; Hydrocarbons; Organic Chemicals; Sulfonic Acids; Sulfur Acids; Sulfur Compounds; Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Glycerophospholipids; Phosphatidic Acids; Glycerophosphates; Phospholipids; Membrane Lipids; Lipids

Study Officials

• Krzysztof Maciej MIZERA, PhD

  1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Krzysztof Maciej Mizera, PhD

CONTACT

+48508356718; krzysztofmizera@o2.pl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants will be randomly assigned to parallel study groups receiving either placebo or multi-ingredient supplementation during the intervention period.

Study Record Dates

• First Submitted: May 13, 2026
• First Posted: May 22, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Locations

HU (1); ES (1); PL (3)