Early CMR in Acute MI

NCT07602439 | Active Not Recruiting

• 1 other identifier: XYFY2026-KL154-01
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate the clinical utility of cardiac magnetic resonance (CMR) in patients with acute myocardial infarction (AMI). This is a retrospective and prospective cohort study that has already enrolled a number of patients and will continue to enroll additional patients on a rolling basis. The main question it aims to answer is: How does CMR, performed acute phase, contribute to risk stratification, prognostic assessment, and long-term clinical management in patients with AMI? Participants who have had an AMI will undergo CMR within one week of symptom onset. After discharge, they will be regularly followed up at 1, 3, 6, 9, and 12 months, and then every 6 months thereafter. Clinical outcomes will be collected during each follow-up visit.

Conditions

Acute Myocardial Infarction (AMI)

Keywords

AMI; CMR

Outcome Measures

Primary Outcomes (1)

• Major Adverse Cardiovascular Events (MACE)

  A composite of cardiovascular death, non-fatal myocardial infarction, unplanned coronary revascularization, and hospitalization for heart failure. Assessed from the date of index hospitalization through the end of follow-up.

  through study completion, an average of 5 years

Secondary Outcomes (1)

• Cardiac Magnetic Resonance (CMR) Imaging Parameters

  Baseline

Study Arms (1)

AMI

Other: Cardiac magnetic resonance imaging

Interventions

Cardiac magnetic resonance imaging OTHER

Cardiovascular magnetic resonance imaging will be used to assess cardiac structure, function, myocardial injury, infarct size, late gadolinium enhancement, microvascular obstruction, and other CMR-derived parameters. This is an observational cohort study, and no diagnostic test or treatment will be assigned by the investigators. CMR examinations have been or will be performed as part of routine clinical evaluation according to clinical indications.

AMI

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with AMI and who underwent CMR within the acute phase of symptom onset.

You may qualify if:

• Patients aged 18 years or older.
• Patients diagnosed with acute myocardial infarction.
• Patients who complete cardiovascular magnetic resonance imaging during the acute phase after symptom onset.
• Patients with available clinical, CMR, and follow-up data.

You may not qualify if:

• History of previous myocardial infarction.
• Severe renal insufficiency, defined as estimated glomerular filtration rate \<30 mL/min/1.73 m².
• Presence of malignant tumors.
• Poor CMR image quality unsuitable for analysis.

Sponsors & Collaborators

• The Affiliated Hospital of Xuzhou Medical University: lead

Study Sites (1)

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221000, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2026
• First Posted: May 22, 2026
• Study Start: October 31, 2018
• Primary Completion (Estimated): March 23, 2046
• Study Completion (Estimated): March 23, 2046
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)