The Relationship Between FAPI Results and Myocardial Fibrosis After Acute Myocardial Infarction

NCT06841549 | Completed

• 1 other identifier: FirstAHXiamenU-Liang
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

FAPI is a new method to discover the fibrosis of cardiac myocardium in some conditions, like myocardial infarction or cardiomyopathy. This purpose of this study is to find the relationship between FAPI results and myocardial fibrosis through some clinical serum inflammatory factors level. Meanwhile, it is the first time to provide the prognostic value of FAPI in the progression of acute myocardial infarction.

Conditions

Acute Myocardial Infarction (AMI)

Outcome Measures

Primary Outcomes (1)

• MACE

  the target vessel failure, heart failure, repeated angina, arrhythmia and all-cause death.

  the first month, the third month, the half year and the next year after acute myocardial infarction

Study Arms (2)

Echo-AMI

acute myocardial infarction followed by echo

FAPI-AMI

acute myocardial infarction followed by FAPI

Other: FAPI

Interventions

FAPI OTHER

FAPI is a new method to find the myocardial fibrosis under some conditions, like myocardial infarction or cardiac myopathy.

FAPI-AMI

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

acute myocardial infarction after successful primary percutaneous intervention.

Sponsors & Collaborators

• The First Affiliated Hospital of Xiamen University: lead

Study Sites (1)

the First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China

Location

Related Publications (1)

• Zhang M, Quan W, Zhu T, Feng S, Huang X, Meng H, Du R, Zhu Z, Qu X, Li P, Cui Y, Shi K, Yan X, Zhang R, Li B. [68Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling. Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):839-848. doi: 10.1007/s00259-022-06015-0. Epub 2022 Nov 3.

  PMID: 36326870 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

acute myocardial infarction

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 19, 2025
• First Posted: February 24, 2025
• Study Start: December 3, 2021
• Primary Completion: January 20, 2025
• Study Completion: January 25, 2025
• Last Updated: February 24, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)