Heart Failure With Preserved Ejection Fraction and Its Cardiac MR Characteristics of Different Subtypes

NCT06916611 | Active Not Recruiting DMC

• 1 other identifier: XYFY2023-KL187-01
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Using cardiac magnetic resonance imaging technology, the ejection fraction of heart failure (HFpEF) and different subtypes of cardiac magnetic resonance characteristics, and combined with the clinical characteristics and prognosis of the patient, explore the value of cardiac magnetic resonance in disease diagnosis, classification, treatment and prognosis, and provide new ideas for clinical practice.

Conditions

HFpEF; Heart Failure With Preserved Ejection Fraction

Keywords

Heart Failure with Preserved Ejection Fraction，HFpEF; Cardiac Magnetic Resonance Imaging，CMR

Outcome Measures

Primary Outcomes (2)

• Rate of Cardiovascular death

  follow - up every 6 months; up to 24 - months

• Rate of readmission of heart failure

  follow - up every 6 months; up to 24 - months

Secondary Outcomes (6)

• Body Temperature

  Baseline

• Blood Glucose Levels

  Baseline

• Brain Natriuretic Peptide (BNP)

  Baseline

• Glycated Hemoglobin (HbA1c)

  Baseline

• Blood Pressure

  Baseline

Study Arms (1)

Patients diagnosed with HFpEF

Diagnostic criteria for HFpEF: * Age = 50 years old ② Cardiac color ultrasound EF 50% ③ Symptoms / signs of heart failure and increased natriuretic peptide levels during hospitalization / visit (BNP 100 pg/mL or NT-proBNP 400 pg / mL).

Other: Cardiac Magnetic Resonance Imaging

Interventions

Cardiac Magnetic Resonance Imaging OTHER

This study included patients who were diagnosed with HFpEF and had completed CMR.

Patients diagnosed with HFpEF

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

In the patients who were diagnosed with "cardiac insufficiency / heart failure" from April 1,2023 to December 31,2026, the medical records were retrieved and the enrolled patients were determined according to the enrollment criteria and the exclusion criteria. Subgroup selection: ① HFpEF combined with hypertension * HFpEF is complicated with type 2 diabetes mellitus ③ HFpEF combined with renal insufficiency ④ HFpEF combined with obesity Control group: ①HFpEF patients

You may qualify if:

• Age is 50 years old.
• Cardiac color ultrasound shows an ejection fraction (EF) of 50% or more.
• Symptoms / signs of heart failure and increased natriuretic peptide levels during hospitalization / visit (BNP 100 pg/mL or NT-proBNP 400 pg / mL).

You may not qualify if:

• Severe liver and kidney insufficiency
• Severe valvular heart disease (severe, severe severe) or known infiltrative or hypertrophic cardiomyopathy
• Malignant tumors and severe hematological diseases
• severe infection
• Autoimmune system diseases

Sponsors & Collaborators

• The Affiliated Hospital of Xuzhou Medical University: lead

Study Sites (1)

the Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221000, China

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 20, 2025
• First Posted: April 8, 2025
• Study Start: May 1, 2023
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 8, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)