NCT07042321

Brief Summary

The goal of this prospective cohort study is to investigate the relationship between the TyG index and early identification of MVO in AMI patients undergoing emergency PCI and CMR imaging. The study will enroll approximately 300 AMI patients treated at Xiangya Third Hospital of Central South University from June 2024 to August 2025. The main questions it aims to answer are:

  • How does the TyG index correlate with the early detection of MVO?
  • What differences in cardiovascular adverse events during hospitalization exist between groups with varying TyG index levels? Participants will undergo emergency PCI and CMR imaging within 3-7 days post-procedure. Data collected will include demographic characteristics, clinical history, coronary angiography data, laboratory test indicators (especially metabolic markers such as blood glucose and lipids), IVUS-related plaque information, and CMR results.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2024

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2024

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

May 28, 2025

Completed
1 month until next milestone

First Posted

Study publicly available on registry

June 29, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2025

Completed
Last Updated

July 2, 2025

Status Verified

June 1, 2025

Enrollment Period

1.2 years

First QC Date

May 28, 2025

Last Update Submit

June 29, 2025

Conditions

Acute Myocardial Infarction (AMI)

Outcome Measures

Primary Outcomes (1)

  • The presence or absence of microvascular obstruction (MVO) diagnosed by cardiac magnetic resonance (CMR) within 3-7 days postoperatively

    3-7 days postoperatively

Study Arms (3)

High TYG Index Group

Medium TYG Index Group

Low TYG Index Group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with acute myocardial infarction

You may qualify if:

  • Age ≥ 18 years.
  • STEMI symptom onset time \< 12 hours.
  • STEMI symptom onset time 12-48 hours, with ongoing ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias.
  • Very high-risk NSTEMI; undergoing emergency PCI treatment.
  • Voluntary signed informed consent form.

You may not qualify if:

  • Non-obstructive acute myocardial infarction.
  • Severe chronic kidney disease (defined as estimated glomerular filtration rate \<20 mL/min per 1.73 m²).
  • Pregnant women or those planning to become pregnant.
  • Failure of emergency PCI.
  • Unclear CMR images

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Xiangya Third Hospital of Central South University

Changsha, Hunan Province,China, 410013, China

RECRUITING

Related Publications (3)

  • Kim MK, Ahn CW, Kang S, Nam JS, Kim KR, Park JS. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc Diabetol. 2017 Aug 23;16(1):108. doi: 10.1186/s12933-017-0589-4.

    PMID: 28830471RESULT

  • Soeda T, Higuma T, Abe N, Yamada M, Yokoyama H, Shibutani S, Ong DS, Vergallo R, Minami Y, Lee H, Okumura K, Jang IK. Morphological predictors for no reflow phenomenon after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction caused by plaque rupture. Eur Heart J Cardiovasc Imaging. 2017 Jan;18(1):103-110. doi: 10.1093/ehjci/jev341. Epub 2016 Jan 22.

    PMID: 26800769RESULT

  • Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome--a new worldwide definition. Lancet. 2005 Sep 24-30;366(9491):1059-62. doi: 10.1016/S0140-6736(05)67402-8. No abstract available.

    PMID: 16182882RESULT

Central Study Contacts

can Zhu Can

CONTACT

+8613348674820zhucan1021@163.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Month
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Cardiology Professor

Study Record Dates

First Submitted

May 28, 2025

First Posted

June 29, 2025

Study Start

June 1, 2024

Primary Completion

August 31, 2025

Study Completion

August 31, 2025

Last Updated

July 2, 2025

Record last verified: 2025-06

Data Sharing

IPD Sharing
Will not share

The nature of the data collected in this study includes sensitive information that is closely tied to the identity of the participants. Out of respect for the privacy and confidentiality of our participants, and in strict adherence to the terms of the informed consent they provided, we are unable to share individual participant data. We believe that protecting the privacy of our participants is of utmost importance, and we are committed to upholding these ethical standards throughout our research.

Locations

CN(1)