Trajectory-Based Phenotyping After Coronary Artery Bypass Surgery

NCT07598682 | Not Yet Recruiting

• 1 other identifier: 2024-TBEK 2026/05-02
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Coronary artery bypass grafting is a commonly performed heart surgery, but patients may have different risks for postoperative complications even when their preoperative risk scores are similar. EuroSCORE II is widely used to estimate surgical risk before cardiac surgery, but it may not fully reflect how the body responds during the early postoperative period. This retrospective observational study will evaluate adult patients who underwent elective coronary artery bypass grafting with cardiopulmonary bypass between January 1, 2022 and December 31, 2025. The study will use existing hospital records and laboratory data. No additional treatment, test, or intervention will be given to patients as part of this study. The main aim is to examine whether early postoperative changes in inflammatory and renal laboratory markers can identify different patient subgroups, called phenotypes. These markers include neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, triglyceride-glucose index, and serum creatinine. The study will evaluate whether these phenotype groups are associated with postoperative acute kidney injury and prolonged intensive care unit stay. The study will also assess whether this early postoperative phenotype-based classification provides additional risk information beyond EuroSCORE II.

Conditions

Coronary Artery Bypass Grafting; Postoperative Acute Kidney Injury; Postoperative Complications; Risk Stratification

Keywords

Coronary artery bypass grafting; Postoperative phenotyping; EuroSCORE II; Risk stratification

Outcome Measures

Primary Outcomes (1)

• Number of Participants With Prolonged Postoperative Intensive Care Unit Stay

  Prolonged postoperative intensive care unit stay was defined as an intensive care unit length of stay exceeding 4 days after elective on-pump coronary artery bypass grafting.

  From surgery to intensive care unit discharge, assessed up to 30 days after surgery

Secondary Outcomes (4)

• Acute Kidney Injury

  Within the first 72 hours after surgery

• In-Hospital Mortality

  From surgery until hospital discharge, assessed up to 30 days after surgery

• Reintubation

  From surgery until hospital discharge, assessed up to 30 days after surgery

• Arrhythmia Requiring Treatment

  From surgery until hospital discharge, assessed up to 30 days after surgery

Study Arms (1)

Elective CABG Cohort

Adult patients who underwent elective coronary artery bypass grafting with cardiopulmonary bypass between January 1, 2022 and December 31, 2025. Patients will be included retrospectively from hospital records, electronic medical records, laboratory databases, and archived patient files. No intervention, experimental treatment, or additional testing will be performed as part of this study.

Other: Early Postoperative Phenotype Classification

Interventions

Early Postoperative Phenotype Classification OTHER

Patients will be retrospectively classified into phenotype groups based on early postoperative inflammatory and renal biomarker trajectories. This classification is analytical only and does not involve any intervention, treatment assignment, or additional testing.

Elective CABG Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult patients who underwent elective on-pump coronary artery bypass grafting at University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital between January 1, 2022 and December 31, 2025. Eligible patients will be identified retrospectively from electronic medical records, laboratory databases, and archived patient files.

You may qualify if:

• Adult patients aged 18 years or older
• Patients who underwent elective on-pump coronary artery bypass grafting
• Patients operated between January 1, 2022 and December 31, 2025
• Patients with available perioperative clinical and laboratory data required for analysis

You may not qualify if:

• Patients undergoing emergency surgery
• Patients undergoing concomitant valve surgery
• Patients with missing or inconsistent key clinical or laboratory data

Sponsors & Collaborators

• Bursa Sevket Yilmaz Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital

Bursa, Turkey (Türkiye)

Location

Related Publications (3)

• Koyuncu AO, Yesiltas MA, Özsoy SD, Mert AM. Comparison of Systemic Inflammation Indices With Post-Cardiac Surgery Mortality and Morbidity. Heart Surg Forum. 2025 Sep 26;28(9). doi:10.31083/HSF46933

  BACKGROUND

• Magouliotis DE, Sicouri N, Ramlawi L, Baudo M, Androutsopoulou V, Sicouri S. Artificial Intelligence in Adult Cardiovascular Medicine and Surgery: Real-World Deployments and Outcomes. J Pers Med. 2026 Jan 30;16(2):69. doi: 10.3390/jpm16020069.

  PMID: 41745362 BACKGROUND

• Silverborn M, Nielsen S, Karlsson M. The performance of EuroSCORE II in CABG patients in relation to sex, age, and surgical risk: a nationwide study in 14,118 patients. J Cardiothorac Surg. 2023 Jan 19;18(1):40. doi: 10.1186/s13019-023-02141-4.

  PMID: 36658617 BACKGROUND

MeSH Terms

Conditions

Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Gürcan Güler

  University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Gürcan Güler

CONTACT

+90 541 975 0407; gurcanguler.45@gmail.com

Gürcan Güler

CONTACT

+90 541 975 04 07; gurcanguler.45@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist Physician, Department of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: May 7, 2026
• First Posted: May 20, 2026
• Study Start: May 7, 2026
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: May 20, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)