Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay

NCT07586059 | Not Yet Recruiting

• 1 other identifier: CIILOS
• Study Type: observational
• Target: 500,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).

Conditions

AKI - Acute Kidney Injury; Critical Illness

Keywords

AKI; CRRT; CKRT; Critical Illness; Intensive care

Outcome Measures

Primary Outcomes (1)

• Intensive care unit (ICU) length of stay (LOS) measured in hours

  Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU)

  ICU LOS during the study period, from admission to discharge, average 168 hours (one week)

Secondary Outcomes (2)

• Mortality

  ONE-YEAR Mortality post admission

• Mechanical ventilation

  Time on mechanical ventilation during the study period, average one week, but up to ICU discharge

Interventions

continuous renal replacement therapy DEVICE

We are evaluting early vs late initiation of CRRT

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All adult critically ill patients in Swedish ICUs from 2010-2023, with- and without the need of CRRT forms this cohort. Within the cohort, a nested case-control type of study can be performed. Two groups: Group 1: Patients with CRRT initiation time less than 30 hours (early CRRT) Group 2: Patients with CRRT initiation time 30 hours or more (late CRRT)

You may qualify if:

• Patients with critical illness
• Admitted to Swedish ICUs from 2010-2023
• Adult (18 years or older)

You may not qualify if:

• \*Patients under 18 years of age

Sponsors & Collaborators

• Karolinska Institutet: lead

MeSH Terms

Conditions

Acute Kidney Injury; Critical Illness

Interventions

Continuous Renal Replacement Therapy

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Renal Replacement Therapy; Therapeutics; Extracorporeal Circulation; Surgical Procedures, Operative

Study Officials

• Max Bell, MD, PhD

  Karolinska University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Max Bell, MD, PhD

CONTACT

+46708278533; max.bell@regionstockholm.se

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, senior lecturer, associate professor

Study Record Dates

• First Submitted: December 18, 2025
• First Posted: May 14, 2026
• Study Start (Estimated): August 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: May 20, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share