Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients

NCT07365111 | Not Yet Recruiting

• 1 other identifier: Pro00160785
• Study Type: observational
• Target: 100,000
• Locations: 1 country
• Sites: 1

Brief Summary

This is a multinational, prospective, observational study designed to characterize patient demographics, prescription parameters, and process measures of continuous renal replacement therapy (CRRT) in intensive care units (ICUs) worldwide. The study aims to examine similarities and differences in CRRT practices and outcomes among critically ill adult patients across a global network of medical centers. The goal is to develop a large, comprehensive repository of data on CRRT practices and outcomes. This repository will enable characterization of variation in standard CRRT practices across medical centers. Natural variability in practice patterns-both between and within centers-will provide an opportunity to compare outcomes associated with different approaches and to generate high-quality preliminary data to inform future interventional trials. Primary Objective \- To describe global patient characteristics, CRRT modalities, and clinical outcomes among patients receiving CRRT. Secondary Objectives

• To compare clinical outcomes across geographic regions and CRRT modalities.
• To identify patient-level and practice-level predictors of outcomes.
• To assess the impact of comorbid conditions (e.g., diabetes mellitus) on CRRT outcomes. Exploratory Objectives
• To evaluate long-term renal outcomes and patient-reported quality of life.
• To explore health economics and resource utilization related to CRRT. Study Population All patients receiving CRRT as part of routine clinical care in the ICU at participating centers will be eligible for inclusion. Data Collection The study will support an epidemiological assessment of patients undergoing CRRT, including, but not limited to, demographics, underlying disease states, severity of illness, physiological support, indications for CRRT, and clinical outcomes. Outcomes of interest include ICU and hospital mortality, ICU and hospital length of stay, and renal recovery.

Conditions

Continuous Renal Replacement Therapy (CRRT); Acute Kidney Injury; Renal Dialysis; Critical Illness

Keywords

Continue Renal Replacement Therapy; Dialysis; Acute Kidney Injury; Intensive Care Unit

Outcome Measures

Primary Outcomes (1)

• Mortality

  Patient survival at the time of ICU discharge

  Up to 28 days

Secondary Outcomes (5)

• Hospital mortality

  Up to 90 days

• ICU length of stay

  Up to 90 days

• Hospital length of Stay

  Up to 90 days

• Renal recovery

  Up to 90 days

• Adverse events

  Up to 90 days

Other Outcomes (2)

• Health Related Quality of Life

  90 and 365 days

• Health Economic Analysis

  Up to 90 days

Study Arms (1)

Patients

Any patients admitted to the ICU and required CRRT

Device: continuous renal replacement therapy

Interventions

continuous renal replacement therapy DEVICE

We will include any critically ill patient admitted to an intensive care unit requiring dialysis

Also known as: CRRT

Patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with new acute kidney injury and initiation of continuous renal replacement therapy who are admitted to an intensive care unit and who have received continuous renal replacement therapy for at least 24 hours will be eligible for this study.

You may qualify if:

• Admission to an intensive care unit
• CRRT therapy

You may not qualify if:

• End-stage kidney disease
• CRRT \<24 hours

Sponsors & Collaborators

• University of Alberta: lead
• University of Alabama at Birmingham: collaborator
• University of Zagreb: collaborator

Study Sites (1)

University of Alberta

Edmonton, Alberta, T6G 2G3, Canada

Location

MeSH Terms

Conditions

Acute Kidney Injury; Critical Illness

Interventions

Continuous Renal Replacement Therapy

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Renal Replacement Therapy; Therapeutics; Extracorporeal Circulation; Surgical Procedures, Operative

Study Officials

• Oleksa Rewa

  University of Alberta

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Oleksa Rewa, MD MSc FRCPC

CONTACT

178026332850; rewa@ualberta.ca

Fadi Hammal, MD MSc

CONTACT

15879907454; hammal@ualberta.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 90 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Director of Research & Innovation

Study Record Dates

• First Submitted: December 17, 2025
• First Posted: January 26, 2026
• Study Start: March 31, 2026
• Primary Completion (Estimated): March 31, 2036
• Study Completion (Estimated): December 31, 2036
• Last Updated: January 26, 2026

Record last verified: 2026-01

Locations

CA (1)