The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis
CRRT
A Randomized Controlled Trial on the Impact of Early Application of CRRT on the Outcomes of Burn Patients With Early Phase of Sepsis
1 other identifier
interventional
60
1 country
1
Brief Summary
The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2011
CompletedFirst Submitted
Initial submission to the registry
December 20, 2011
CompletedFirst Posted
Study publicly available on registry
December 29, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedDecember 30, 2011
December 1, 2011
2 years
December 20, 2011
December 28, 2011
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in serum cytokine concentrations and clearance
0, 6, 12 , 24, 48, 96 hours post CRRT
96 hours
Secondary Outcomes (1)
28 and 90 days survival
90 days
Study Arms (2)
Control group
NO INTERVENTIONearly HV-crrt
EXPERIMENTALInterventions
Patients will be randomized to either arm :early HV-crrt(50ml/kg/h) or Control group
Eligibility Criteria
You may qualify if:
- patients with documented sepsis
- age 18 to 70 years
- severe burned patients with 50% \< TBSA \< 85%
You may not qualify if:
- cirrhosis child class C
- too high APACHE II \& SOFA score at admission
- age over 70 years
- were presence of a malignant tumor, chronic renal insufficiency (serum creatinine \> 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Southwest Hospital
Chongqing, Chongqing Municipality, 400038, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
December 20, 2011
First Posted
December 29, 2011
Study Start
December 1, 2011
Primary Completion
December 1, 2013
Last Updated
December 30, 2011
Record last verified: 2011-12