The Effect of Continuous Renal Replacement Therapy on the Efficiency of Extracorporeal CO2 Removal

NCT05989971 | Completed

• 1 other identifier: 20230731
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

In the design of extracorporeal carbon dioxide removal (ECCO2R) combined with continuous renal replacement therapy (CRRT) equipment, in model of continuous veno-venous hemofiltration (CVVH) , the HCO3- concentration in the pre membrane lung blood is diluted by the replacement solution, and a decrease in HCO3- leads to a decrease in PCO2. On the other hand, in continuous veno-venous hemodialysis (CVVHD), HCO3- in post membrane blood will exchange interaction. The exchange results of HCO3- determine the impact of CVVHD on the CO2 removal efficiency of the ECCO2R combined CRRT system. This study aims to investigate the effects of CVVH and CVVHD on in vitro CO2 clearance efficiency.

Conditions

Respiratory Failure With Hypercapnia

Outcome Measures

Primary Outcomes (1)

• extracorporeal CO2 removal rate

  extracorporeal CO2 removal rate was calculated as the difference of total CO2 content before membrane lung and after hemofilter, and normalized to an inlet PCO2 of 45 mmHg

  after 30min of continuous renal replacement therapy

Study Arms (1)

Extracorporeal carbon dioxide removal combined with continuous renal replacement therapy

extracorporeal carbon dioxide removal combined with continuous veno-venous hemofiltration or continuous veno-venous hemodialysis.CVVH and CVVHD set-up: predilution 30 ml/kg/h, dialysate dose 30 ml/kg/h, ultrafiltration rate was equal to the total rate of substitution fluid infusion.

Other: continuous renal replacement therapy

Interventions

continuous renal replacement therapy OTHER

continuous veno-venous hemofiltration or continuous veno-venous hemodialysis set-up: predilution 30 ml/kg/h, dialysate dose 30 ml/kg/h, ultrafiltration rate was equal to the total rate of substitution fluid infusion

Extracorporeal carbon dioxide removal combined with continuous renal replacement therapy

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

using Extracorporeal carbon dioxide removal combined with continuous renal replacement therapy

You may qualify if:

• Using Extracorporeal carbon dioxide removal combined with continuous renal replacement therapy
• years ≤ age ≤ 85 years;

You may not qualify if:

• Severe hemodynamic instability (increased dosage of vasoactive drugs or MAP ≤ 65mmHg within two hours);
• Severe electrolyte deficiency (including severe hyponatremia (blood sodium\<130mmol/L) and hypokalemia (blood potassium\<3.0mmol/L));
• Participate in other intervention studies within 30 days;
• Do not consent this research

Sponsors & Collaborators

• Southeast University, China: lead

Study Sites (1)

Ling Liu

Nanjing, Jiangsu, 210009, China

Location

MeSH Terms

Interventions

Continuous Renal Replacement Therapy

Intervention Hierarchy (Ancestors)

Renal Replacement Therapy; Therapeutics; Extracorporeal Circulation; Surgical Procedures, Operative

Study Officials

• Ling Liu

  Zhongda Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: deputy director

Study Record Dates

• First Submitted: July 31, 2023
• First Posted: August 14, 2023
• Study Start: April 24, 2023
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2025
• Last Updated: January 22, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)